Overactive bladder, which is also known as OAB is basically a frequent urge to urinate that is difficult to control. It’s not a disease. One feels like they need to pass urine a lot of times during the whole day and even night. In overactive bladder the muscles of the bladder contract on their own even when volume of urine is less in the bladder.
People with OAB also suffer from urgency incontinence (unintentional loss of urine).
OVERACTIVE BLADDER SYMPTOMS:
Overactive bladder has various kinds of symptoms that includes:
- Frequency of urination: Patients with this symptom need to urinate frequently. It’s an increase in the number of times a normal person urinates usually.
- Nocturia: It’s the need to get up and urinate more than twice every night.
- Urinary urgency: This means the person with an overactive bladder has a limited amount of time to go to the bathroom.
- Urgency incontinence: In this there’s a leakage of urine when there’s an urge to urinate.
OVERACTIVE BLADDER CAUSES:
- Diabetes: Diabetic patients tend to have overactive bladder
- Neurological disorders such as sclerosis and strokes
- Hormonal changes during menopause
- Urinary tract infections can also cause symptoms which are similar to those of an overactive bladder
- Bladder stones
- Certain tumors
- Different factors such as enlarged prostate, constipation etc.
Does dehydration cause overactive bladder?
There’s a misconception that if the person with an overactive bladder limits their fluid intake it’ll help with urinary incontinence. Infact, not drinking enough will only distress the bladder and worsen overactive bladder symptoms.
Overactive Bladder Treatment in Pakistan
The treatment of overactive bladder in Pakistan is easily resolved with a the correct doctor consultation. Since the severity of the condition varies from age and condition and the types of incontinence. Usually, a combination of treatments is needed for a successful recovery from frequent urination in women.
The treatments for OAB usually consist of behavior therapy techniques, pelvic muscle exercises, and medications for urinary incontinence. Most common medicine for overactive bladder is Solifen tablet in Pakistan which should ONLY be used when prescribed by your doctor.
carnosine (beta-alanyl-l-histidine) is a dipeptide molecule, made up of the amino acids beta-alanine and histidine. it is highly concentrated in muscle and brain tissues.[citation needed]
carnosine and carnitine were discovered by russian chemist vladimir gulevich. it has been proven to scavenge reactive oxygen species (ros) as well as alpha-beta unsaturated aldehydes formed from peroxidation of cell membrane fatty acids during oxidative stress. it also buffers ph in muscle cells, and acts as a neurotransmitter in the brain. it is also a zwitterion, a neutral molecule with a positive and negative end.[citation needed]
like carnitine, carnosine is composed of the root word carn, meaning “flesh”, alluding to its prevalence in animal protein. there are no plant-based sources of carnosine. therefore, a vegetarian or vegan diet provides little or no carnosine in comparison to the amounts found in a diet that includes meat.
carnosine can chelate divalent metal ions.
carnosine can increase the hayflick limit in human fibroblasts, as well as appearing to reduce the telomere shortening rate. it is also considered as a geroprotector.
biosynthesis
carnosine is synthesized in vivo from beta-alanine and histidine. since beta-alanine is the limiting substrate, supplementing just beta-alanine effectively increases the intramuscular concentration of carnosine.
physiological effects
carnosine has a pka value of 6.83, making it a good buffer for the ph range of animal muscles. since beta-alanine is not incorporated into proteins, carnosine can be stored at relatively high concentrations (millimolar). occurring at 17–25 mmol/kg (dry muscle), carnosine (ß-alanyl-l-histidine) is an important intramuscular buffer, constituting 10-20% of the total buffering capacity in type i and ii muscle fibres.
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