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Primary Biliary Cirrhosis

Description

Primary Biliary Cirrhosis, now known as Primary Biliary Cholangitis (PBC), is an autoimmune disease of the liver in which the body attacks its own healthy cells. It causes gradual, progressive destruction of the small bile ducts of the liver; this leads to the buildup of bile and other toxins. The accumulation of bile and toxins results in a condition known as Cholestasis.

Causes

The exact cause for Primary Biliary Cholangitis is unknown. However, researchers believe that it occurs when the body attacks its own cells. Primarily, the T-lymphocytes, a type of white blood cells, attack the liver’s healthy cells leading to significant damage.

The inflammation associated with cell damage spreads to other liver cells, gradually impairing liver functions. The damaged cells are replaced by scar tissue (fibrosis), which leads to cirrhosis. Scarring of the liver tissue, Cirrhosis, makes it difficult for the liver to work properly.

Risk factors

The following are the risk factors:

  • Gender, women are at a higher risk
  • Age, 30-50 years’ individuals are more likely to develop it
  • Family history
  • Infections
  • Smoking
  • Exposure to toxins
Symptoms

The following are the symptoms:

  • Itchy skin
  • Fatigue
  • Dry eyes and mouth
  • Pain in the upper right abdomen
  • Swelling of the spleen
  • Bone, muscle, or joint pain
  • Nausea and vomiting
  • Fluid buildup in the abdomen
  • Jaundice (yellowing of the skin and eye)
  • Swelling of the feet and ankles
  • Hyperpigmentation (dark spots)
  • Xerostomia (dry mouth)
  • High cholesterol
  • Osteoporosis (weak and brittle bones)
Diagnosis

The diagnosis is made when a doctor examines the patient physically, checks relevant symptoms, and performs certain lab tests, such as cholesterol tests, liver function tests, and antibody test for signs of autoimmune disorders.

Management

Following is the management:

  • Regular and directed use of prescribed medicines
  • Antihistamines
  • Corticosteroids
  • Avoidance of foods that may be triggering symptoms
  • Avoidance of allergens that may be triggering symptoms

Please consult your doctor for further information.

When to consult a doctor?

Early diagnosis can lead to effective and successful treatment. If your symptoms do not improve within a few days, or you experience any of the symptoms mentioned above, such as upper abdomen pain, itching, and discomfort, please see a doctor.

 

 

Available Medicine for Primary Biliary Cirrhosis

Urso 250mg

Rs.600

AGP

Urso 500mg

Rs.1000

AGP

Urso

Rs.1400

AGP

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