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Amlodipine is approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called dihydropyridine calcium channel blockers. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers lower the incidence of myocardial depression and cardiac conduction abnormalities than caused by other calcium channel blockers.

Amlodipine is commonly used in the treatment of high blood pressure and angina. Amlodipine has antioxidant properties and an ability to enhance the production of nitric oxide (NO), an important vasodilator that decreases blood pressure . The option for single daily dosing of amlodipine is an amazing feature of this drug.


Cardiogenic shocks, aortic stenosis, unstable angina, left ventricular outflow obstruction, severe hypotension, unstable heart failure following MI, hypersensitivity to dihydropyridines.

Side effects

Headache, edema, fatigue, nausea, flushing and dizziness, rash, alopecia, angioedema, palpitations, dyspnoea, abdominal pain, back pain

Expert Advice

Take with or without meals, to prevent stomach upset take with meals, contact prescriber if there is unrelieved headaches, vomiting, constipation, palpitation, arm, leg or facial swelling, weight gain or difficulty in breathing