Acarbose C25H43NO18
Molecular Weight: 645.608 g/mol
Dissociation Constant: 5.1
Indication
It is primarily indicated for treating Diabetes Mellitus type 2, used in combination with other line agents.
Mechanism of Action
Acarbose is known to be pseudotetrasacchride that inhibits absorption of glucose by delayed ingestion by inhibiting the pancreatic aplha amylase enzyme and alpha glucosidase enzyme present in the brush border of the intestine which prevents the breakdown of complex carbohydrates into monosacchride and starch
Dosage
Strength: 100mg
Form: tablet
Dosing interval: 8 Hr
Maximum Dose: Research suggests that the maximum dose given to an individual of 60kg or less should be 50 mg (8-hourly) and above 60kg should be 100mg (8-hourly)
Dialyzable:Data not available, so not recommended or monitor with care.
Maintainance dose
It is suggested to start the dose with 25mg three times a day and can be increased upto 50-100mg three times a day depending upon tolerance and glucose levels (HbA1C, random and fasting blood glucose test)
Hepatic Adjustment
It is suggested to obtain transaminase level before initiation in liver insufficiency to prevent worsened conditions.
Renal Adjustment
It is advised to take cautiously when serum creatinine levels are less than 2mg/dl
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Pregnancy
Can be used but doctor consultation is important before use, as human and animal research is insufficient or animals showed defects and human research hasn?t been conducted.
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Lactation
Insufficient data to prove if the drug enters breast milk, hence not recommended.
ContraIndication
Cautions
Evidences of severe hypoglycemia reported when using along with insulins and sulfonylureas. Incidents like; Trauma,surgery, stress and fever have proven to cause loss over glucose regulation
Pharmacokinetics
Time of onset: 1 Hr
Tmax: 0.32 Litres per kg
Bioavailability: less than 2%
Protein Binding : It is known to be greater than 99% as per reported data.
Elimination Half Life (t1/2): 2 Hr
Metabolism: By digestive system as per researches.
Volume of Distribution (Vd): 0.32 Litres per kg
Metabolites:
4-Methylpyrgallol derivatives as inactive metabolite
Medicine Overview of Glucobay 100mg tablet
Uses of Glucobay
This medicine is used for managing non-insulin dependent diabetes
Side effects of Glucobay
Some patients might experience stomach bloating, stomach pain and diarrhoea. Please consult your doctor if you experience any of these symptoms.
When not to use Glucobay
Please consult your doctor before taking this medicine if you have any of these conditions; Hepatic or renal impairment (liver or kidney disorder) or any of the following stomach disorders like inflammatory bowel disorders, chronic ulcerations, intestinal obstructions, or chronic digestive or absorption problems.
How to take Glucobay
This medicine should be taken with food.
Warnings
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Driving
Please avoid driving when taking this medicine as it may affect your ability to drive.
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Pregnancy
Please consult your doctor before taking this medicne.
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Breast Feeding
Research suggests that this medicine should be avoided by women who are breastfeeding.
What side-effects did you experience while using this medicine?
- stomach pain 1
- skin rash 0
- flatulence 0
- diarrhea 0
- None 0
How did you take this medicine?
With food
With or without food
Empty Stomach
How much was the improvement?
1
2
3
4
5
What are you using this medicine for?
Type 2 diabetes
Others
Number of survey's Available: 1
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