Molecular Weight: 645.608 g/mol
Dissociation Constant: 5.1
It is primarily indicated for treating Diabetes Mellitus type 2, used in combination with other line agents.
Mechanism of Action
Acarbose is known to be pseudotetrasacchride that inhibits absorption of glucose by delayed ingestion by inhibiting the pancreatic aplha amylase enzyme and alpha glucosidase enzyme present in the brush border of the intestine which prevents the breakdown of complex carbohydrates into monosacchride and starch
Dosing interval: 8 Hr
Maximum Dose: Research suggests that the maximum dose given to an individual of 60kg or less should be 50 mg (8-hourly) and above 60kg should be 100mg (8-hourly)
Dialyzable:Data not available, so not recommended or monitor with care.
It is suggested to start the dose with 25mg three times a day and can be increased upto 50-100mg three times a day depending upon tolerance and glucose levels (HbA1C, random and fasting blood glucose test)
It is suggested to obtain transaminase level before initiation in liver insufficiency to prevent worsened conditions.
It is advised to take cautiously when serum creatinine levels are less than 2mg/dl
Can be used but doctor consultation is important before use, as human and animal research is insufficient or animals showed defects and human research hasn?t been conducted.
Insufficient data to prove if the drug enters breast milk, hence not recommended.
Evidences of severe hypoglycemia reported when using along with insulins and sulfonylureas. Incidents like; Trauma,surgery, stress and fever have proven to cause loss over glucose regulation
Time of onset: 1 Hr
Tmax: 0.32 Litres per kg
Bioavailability: less than 2%
Protein Binding : It is known to be greater than 99% as per reported data.
Elimination Half Life (t1/2): 2 Hr
Metabolism: By digestive system as per researches.
Volume of Distribution (Vd): 0.32 Litres per kg
4-Methylpyrgallol derivatives as inactive metabolite
Medicine Overview of Glucobay 100mg tablet
Uses of Glucobay
This medicine is used for managing non-insulin dependent diabetes
Side effects of Glucobay
Some patients might experience stomach bloating, stomach pain and diarrhoea. Please consult your doctor if you experience any of these symptoms.
When not to use Glucobay
Please consult your doctor before taking this medicine if you have any of these conditions; Hepatic or renal impairment (liver or kidney disorder) or any of the following stomach disorders like inflammatory bowel disorders, chronic ulcerations, intestinal obstructions, or chronic digestive or absorption problems.
How to take Glucobay
This medicine should be taken with food.
Please avoid driving when taking this medicine as it may affect your ability to drive.
Please consult your doctor before taking this medicne.
Research suggests that this medicine should be avoided by women who are breastfeeding.
What side-effects did you experience while using this medicine?
- stomach pain 1
- skin rash 0
- flatulence 0
- diarrhea 0
- None 0
How did you take this medicine?
With or without food
How much was the improvement?
What are you using this medicine for?
Type 2 diabetes
Number of survey's Available: 1