OVERVIEW
Cryoglobulins are immunoglobulins (i.e., IgG, IgM, IgA or light chains), that precipitate when they are
exposed to cold and dissolve when warmed. They are present in small quantities in the blood of some
healthy people but are most frequently associated with abnormal protein production and a variety of
diseases and conditions.
- Type I: This type is often seen in people with myeloma or lymphoma.
- Type II: This type is often seen in people with hepatitis C or other viral infections.
- Type III: This type is often seen in people with autoimmune diseases.
WHAT DOES THE TEST MEASURE?
This test detects and measures the relative quantity of cryoglobulins in the blood.
FREQUENTLY ASKED QUESTIONS:
How is this test performed?
This test is performed on a blood sample. The blood is obtained from the vein and this is performed by a
a healthcare provider in the following way.
- clean the skin
- put an elastic band above the area
- insert a needle into a vein (usually in the arm inside of the elbow or on the back of the hand)
- pull the blood sample into a vial or syringe
- take off the elastic band and remove the needle from the vein
What are the risks associated with this test?
There is no significant risk associated with this test. A small bruise or mild soreness around the blood
test site is common and can last for a few days. Get medical care if the discomfort gets worse or lasts
longer.
What are the symptoms of cryoglobulinemia?
- Change of the color of hands or feet
- Weight loss
- High blood pressure
- Swelling of ankles and legs
INTERPRETATION OF THE RESULT:
The cryoglobulins test is negative (no cryoglobulins found) in most healthy people and is not routinely ordered for those without symptoms.
A positive test for cryoglobulins may be seen in numerous conditions. Some examples include:
- Infections such as hepatitis, hiv/aids.
- Kidney disease
- Autoimmune diseases