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ACTH Stimulation Test (Short Synacthen Test)

Rs. 2,805

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  • WHAT DO YOU NEED TO PROVIDE: This test will be performed on a  blood sample.
  • WHO IS THE TEST CONDUCTED ON? Males and females. 
  • TEST PREPARATION: The test is done the following way: 1- Your blood is drawn. 2- You then receive a shot (injection) of ACTH, usually into the muscle in your shoulder. The ACTH may be a man-made (synthetic) form. 3- After either 30 minutes or 60 minutes, or both, depending on how much ACTH you receive, your blood is drawn again. 4- The lab checks the cortisol level in the blood samples.

 

You may need to limit activities and eat foods that are high in carbohydrates 12 to 24 hours before the test. You may be asked to fast for 6 hours before the test. Sometimes, no special preparation is needed. You may be asked to temporarily stop taking medicines, such as hydrocortisone, which can interfere with the cortisol blood test

 

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Overview 

 

The ACTH stimulation test measures how well the adrenal glands respond to adrenocorticotropic hormone (ACTH). ACTH is a hormone produced in the pituitary gland that stimulates the adrenal glands to release a hormone called cortisol.

 

 

 

TEST INTERPRETATIONS:

 

Normal Results

An increase in cortisol after stimulation by ACTH is expected. Cortisol level after ACTH stimulation should be higher than 18 to 20 mcg/dL or 497 to 552 nmol/L, depending on the dose of ACTH used.

 

Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or may test different specimens. Talk to your provider about the meaning of your specific test results.

 

What Abnormal Results Mean

This test is helpful in finding out if you have:

 

  • Acute adrenal crisis (a life-threatening condition that occurs when there is not enough cortisol)
  • Addison disease (adrenal glands do not produce enough cortisol)
  • Hypopituitarism (pituitary gland is not producing enough hormones such as ACTH)

WHY GET TESTED?

This test can help determine whether your adrenal and pituitary glands are normal. It is most often used when your healthcare provider thinks you have an adrenal gland problem, such as Addison disease or pituitary insufficiency. It is also used to see if your pituitary and adrenal glands have recovered from prolonged use of glucocorticoid medicines, such as prednisone.

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