WHAT IS BETA 2 GLYCOPROTEIN-1 IgM TEST?
Autoantibodies areantibodies(immune proteins) that mistakenly target and react with a person's own tissues or organs. One or more autoantibodies may be produced by a person'simmune systemwhen it fails to distinguish between "self" and "non-self."
’ ANTIPHOSPHOLIPID SYNDROME (APS) IgM ANTIBODIES:<span color:#231f20;="" font-family:calibri,sans-serif;="" font-size:11.0pt;="" mso-ascii-theme-font:minor-latin;="" mso-bidi-font-family:arial;="" mso-hansi-font-family:arial"=""> Largest antibody, and is the first antibody to appear in response to initial exposure to antigen.
WHAT DOES THE TEST MEASURE?
- A positive beta- 2 glycoproteins IgM antibody test indicates that the person has Antiphospholipid syndrome, as they are most frequently see with the condition.
- A negative beta- 2 glycoproteins IgM antibody but positive for other antiphospholipid antibodies and has signs and symptoms, then the person has APS.
- A single positive beta-2 glycoprotein 1 antibody result is not diagnostic of APS, and a negative result does not rule out antiphospholipid antibody development. They just indicate the presence or absence of the antibody at the time of testing. That is why a diagnosis of APS requires clinical symptoms plus at least two positive tests for an antiphospholipid antibody at least 12 weeks apart.
WHY IS THIS TEST PERFORMED?
- To help investigate inappropriate blood clot formation
- To help investigate the cause of recurrent miscarriages
- As part of an evaluation for antiphospholipid syndrome