Autoantibodies areantibodies(immune proteins) that mistakenly target and react with a person's own tissues or organs. One or more autoantibodies may be produced by a person'simmune systemwhen it fails to distinguish between "self" and "non-self."
’ ANTIPHOSPHOLIPID SYNDROME (APS) IgM ANTIBODIES:<span color:#231f20;="" font-family:calibri,sans-serif;="" font-size:11.0pt;="" mso-ascii-theme-font:minor-latin;="" mso-bidi-font-family:arial;="" mso-hansi-font-family:arial"=""> Largest antibody, and is the first antibody to appear in response to initial exposure to antigen.
WHAT DOES THE TEST MEASURE?
A positive beta- 2 glycoproteins IgM antibody test indicates that the person has Antiphospholipid syndrome, as they are most frequently see with the condition.
A negative beta- 2 glycoproteins IgM antibody but positive for other antiphospholipid antibodies and has signs and symptoms, then the person has APS.
A single positive beta-2 glycoprotein 1 antibody result is not diagnostic of APS, and a negative result does not rule out antiphospholipid antibody development. They just indicate the presence or absence of the antibody at the time of testing. That is why a diagnosis of APS requires clinical symptoms plus at least two positive tests for an antiphospholipid antibody at least 12 weeks apart.
WHY IS THIS TEST PERFORMED?
To help investigate inappropriate blood clot formation
To help investigate the cause of recurrent miscarriages
As part of an evaluation for antiphospholipid syndrome