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Glimepiride + Metformin

Indication

It is primarily indicated for treating Diabetes Mellitus type 2 uncontrolled by metformin or glimepiride alone.

Mechanism of Action

It increases B cell insulin secretion, receptors and sensitivity. It also decreases the liver production of glucose. A combination of both the ingredients offers a controlled glucose level in blood in diabetes type 2 and prevents vascular complications in patients where metformin alone is insufficient.

Dosage

Strength: 2mg/500mg

Form: tablet

Dosing interval: 24 Hr

Maximum Dose: 8/2000mg per day

Dialyzable:Metofrmin: yes

Maintainance dose

1/500mg once daily then adjust the dose according to the dose response.

Renal Adjustment

Adjust the dose if Creatinine clearence of the patient is greater then 1.5mg/dl and 1.4mg/dl in females.

  • pregnant

    Pregnancy

    Doctors consultation is important before use, as human and animal research is insufficient or animals showed defects and human research hasn?t been conducted.

  • mother

    Lactation

    The use of combination product in nursing mothers is not recommended.

ContraIndication
Cautions

Use with great care if the patient had suffered from cardiovascular events inclusiding hypoxic conditions. It is generally not recommended to be used in patients with metabolid acidosis (diabetic ketoacidosis). Alocholic or hypoglycemic patients should be instructed properly when taking sulfonylureas. Patients with a 6GDP (6-phosphate dehydrogenase) leads to severe anemia, so care should be taken with prescribing a sulfonylurea (Glimepride) when taken along with non-sulfonylureas.

Pharmacokinetics

Time of onset: 1 hr (delayed to about 12% if taken with meals, known to be insignificant)

Disclaimer

Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.

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