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Chlorpropamide C10H13ClN2O3S

Molecular Weight: 277g/mol
Dissociation Constant: 5.13

It is primarily indicated for treating Diabetes Mellitus type 2. Off-label (Non FDA approved): Neurogenic Diabetes insipidus.

Mechanism of Action

It Increases pancreatic B cell insulin secretion, receptors and sensitivity. Study shows that it decreases the liver production of glucose as per studies.


Strength: 250mg

Form: tablet

Dosing interval: 24 Hr

Maximum Dose: Less than 750mg per day

Dialyzable:Hepatic and Renal: No

Maintainance dose

Higher doses of 500mg used as maintenance for severe diabetic patient as per recommendations.

Hepatic Adjustment

It is recommended to start with extreme lower doses for initiation and maintenance of the medicine treatment therapy

Renal Adjustment

If creatinine clearence is less than 50ml/min, the study suggests to not consider chlorpropamide for treatment therapy. However, in case if creatinine clearence is greater than 50ml/min, treatment doses should be extremely less to avoid low glucose conditions.

  • pregnant


    Can be used but doctor consultation is important before use, as human and animal research is insufficient or animals showed defects and human research hasn?t been conducted.

  • mother


    Insufficient data to prove if the drug enters breast milk, hence not recommended.


Administration of this drug requires critical monitoring in patients with liver and kidney insufficiencies and elderly group of population. Patients who are at risk of extremely lowered glucose value and patients with extreme lean bodies also require careful initiation of the treatment as per reported clinical studies.


Time of onset: 1 hr. Diabetes Insipidus: 24 Hr

Tmax: 0.13-0.20 l/kg

Bioavailability: more than 90% as per studies.

Protein Binding : 60-90%

Elimination Half Life (t1/2): 25-48Hr

Metabolism: Extensive via liver (80%)

Volume of Distribution (Vd): 0.13-0.20 l/kg


Inactive: chlorobenzene-sulfonylurea, active: hydroxychlorpramide


Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.


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