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It is primarily indicated for treating Diabetes Mellitus type 2. Off-label (Non FDA approved): Neurogenic Diabetes insipidus.
It Increases pancreatic B cell insulin secretion, receptors and sensitivity. Study shows that it decreases the liver production of glucose as per studies.
Dosing interval: 24 Hr
Maximum Dose: Less than 750mg per day
Dialyzable:Hepatic and Renal: No
Higher doses of 500mg used as maintenance for severe diabetic patient as per recommendations.
It is recommended to start with extreme lower doses for initiation and maintenance of the medicine treatment therapy
If creatinine clearence is less than 50ml/min, the study suggests to not consider chlorpropamide for treatment therapy. However, in case if creatinine clearence is greater than 50ml/min, treatment doses should be extremely less to avoid low glucose conditions.
Can be used but doctor consultation is important before use, as human and animal research is insufficient or animals showed defects and human research hasn?t been conducted.
Insufficient data to prove if the drug enters breast milk, hence not recommended.
Administration of this drug requires critical monitoring in patients with liver and kidney insufficiencies and elderly group of population. Patients who are at risk of extremely lowered glucose value and patients with extreme lean bodies also require careful initiation of the treatment as per reported clinical studies.
Time of onset: 1 hr. Diabetes Insipidus: 24 Hr
Tmax: 0.13-0.20 l/kg
Bioavailability: more than 90% as per studies.
Protein Binding : 60-90%
Elimination Half Life (t1/2): 25-48Hr
Metabolism: Extensive via liver (80%)
Volume of Distribution (Vd): 0.13-0.20 l/kg
Inactive: chlorobenzene-sulfonylurea, active: hydroxychlorpramide
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