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This medicine is used for managing maturity onset diabetes

Some patients might experience Nausea. Pease consult your doctor if you experience any of these symptoms.

Please consult your doctor before taking this medicine if you have any of these conditions; Juvenile diabetes with Ketosis (type of diabetes), impairment of renal function (kidney disorder), stress, diabetic coma.

This medicine should be taken with food.

Avoid this medication if:

  • You are allergic to this medicine or it's contents, (Sulfa, etc.)

Consult your doctor if:

  • You are pregnant, planning to have a child, or breastfeeding.
  • You have any sort of digestive problems
  • You have a medical history of: Liver diseases, kidney diseases, thyroid problems, blood disorders, etc.
  • You are considered an elderly patient, since this medicine may cause low blood sugar in such patients.
  • Inform your physician about any other medication you are taking.

Be careful about:

  • Having your meals on time to maintain blood sugar levels
  • Taking the medicine timely, in the way that your physician has prescribed (with food)
  • Following the lifestyle changes that your physician has suggested.
Type II Diabetes
It belongs to a class of drugs known as sulfonylureas. These drugs are used in the treatment of diabetes.
This is a possible side effect, but can be avoided if meals are taken regularly.
If it has not been too long, have the skipped dose with your next meal. If it is almost time to take your next dose, do not take two doses, simply return to the prescribed routine.
If you are not regular with your meals, you may experience symptoms of low blood sugar: Such as palpitation, sweating, dizziness, light headedness etc. In this case, taking sugar can relieve your symptoms.
Kindly avoid taking any medication beyond the mentioned date of expiry.
No. Please consult your doctor if you suffer from a liver or a kidney disease.
No. This drug is not recommended for use in pregnancy. Please consult your doctor before using it during pregnancy.
No. The use of this medication is not recommended for use during lactation. Please consult your doctor before using this drug during breast feeding.
Some of the blood pressure lowering drugs may enhance the effect of glibenclamide causing hypoglycemia. Please consult your doctor for further assistance.
If your doctor has recommended using this drug with insulin then it should be added to your treatment. However, it is advised to strictly follow the prescribed doses , as failure to do may cause symptoms of hypoglycemia (low blood sugar) such as; dizziness, light headedness, palpitations etc.
No. This medicine is only for use in type 2 diabetes.
Yes, this medicine can be given to elderly patients but regular dose monitoring is important because older patients are more prone to the development of low blood sugar. Please consult your doctor for further guidance.
Please consult your doctor before taking this medicne.
Research suggests that this medicine should be avoided by women who are breastfeeding.
Please avoid driving when taking this medicine as it may affect your ability to drive.
Please avoid consuming alcohol when taking this medicine.
Please consult your doctor as a precaution before taking this medicine if you have cross-sensivity to sulfonamides and sulfonamide derivative (type of antibiotic).

Glibenclamide C23H28ClN3O5S

Molecular Weight: 494g/mol
Dissociation Constant: 4.7

It is primarily indicated for treating Diabetes Mellitus type 2. Orphan (rare medication use): Acute spinal cord injury, stroke and hemorrhage

Mechanism of Action

It increases B cell insulin secretion, receptors and sensitivity. It also decreases the liver production of glucose


Strength: 5mg

Form: tablet

Dosing interval: Every 24 hours usually. Administer every 12 hourly for doses less than 10mg

Maximum Dose: 20mg per day

Dialyzable:The medicine is not dialyzable. Hence, suggested to avoid in renal insufficient patients.

Maintainance dose

Studies suggests to start with a dose of 2.5-5mg per day then adjust up to 7.5-12mg per day.

Hepatic Adjustment

It has been suggested to start with 1.25mg of Glibenclamide initially in patients who have a compromised liver functioning as per studies.

Renal Adjustment

It is not suggested in patients with Creatinine Clearence less than 50ml/min: Suggested to be used with caution.

  • pregnant


    Doctors consultation is important before use, as human and animal research is insufficient or animals showed defects and human research hasn?t been conducted.

  • mother


    Insufficient data to prove if the drug enters breast milk, hence not recommended.


Should be taken with great care in patients who have renal and kidney dysfunction. Also it is suggested to observe blood levels for anemic conditions that might develop due to 6-phosphate glucose dehydrogenase deficiency conditions. Pregnant and nursing mothers should be closely monitored for altered glucose levels.


Time of onset: 1 Hr

Tmax: 9.5 Liters

Bioavailability: Variable

Protein Binding : 99%

Elimination Half Life (t1/2): 1.4-1.8 Hr for active drug. Ten hours for metabolites.

Metabolism: Less metabolites formed through extensive liver metabolism

Volume of Distribution (Vd): 9.5 Liters


Active: 3-cis-hydroxyglyburide


Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.


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