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This medicine is used in the management of type 2 diabetes particularly in overweight patients.

Some patients might experience visual disturbance and Respiratory infection. Please consult your doctor if you experience any of these symtpoms

Please consult your doctor before taking this medicine if you have any of these conditions; hepatic impairment, cardiac failure or history of cardiac failure.

This medicine should be taken with food.

Avoid this medication if:

  • You are allergic to this medicine or its contents.

Consult your doctor if:

  • You are pregnant, planning to have a child, or breastfeeding.
  • You have any sort of digestive problems
  • You have a medical history of: Liver diseases, kidney diseases, heart diseases, or bladder cancers.
  • Inform your physician about any other medication you are taking.
  • You experience weakness in your bones
  • You experience breathing difficulties (due to swelling in the lungs)

Be careful about:

  • Having your meals on time to maintain blood sugar levels
  • Taking the medicine timely, in the way that your physician has prescribed.
  • Weight gain, as it is a possible side effect of this medicine.

 

Type II diabetes

This medication is used for managing non-insulin dependent diabetes

Some patients might experience hypoglycemia and liver failure. Please consult your doctor if you experience any of these symptoms.

Please consult your doctor before taking this medication if you have any of these conditions; insulin-dependent diabetes mellitus (type of diabetes), or diabetic Ketoacidosis (diabetic complication).

This medicine should be taken with food.

Avoid this medication if:

  • You are allergic to this medicine or it's contents (Sulfa, etc.)

Consult your doctor if:

  • You are pregnant, planning to have a child, or breastfeeding.
  • You have any sort of digestive problems.
  • You have a medical history of: Liver diseases, kidney diseases, thyroid problems, blood disorders, etc.
  • Inform your physician about any other medication you are taking. Especially NSAIDs, thyroid medicines or blood pressure medications (such as Beta Blockers, or ACE inhibitors.)

Be careful about:

  • Having your meals on time to maintain blood sugar levels
  • Taking the medicine timely, in the way that your physician has prescribed (with food)
  • Following the lifestyle changes that your physician has suggested.
  • Alcohol consumption should be avoided.
Type II Diabetes
It belongs to a class of drugs known as glitazones, or thiazolidinediones
This is a possible side effect, but can be avoided if meals are taken regularly. Try to carry sugar or a sugary drink in case you experience lightheadedness, or any other symptoms of low blood sugar.
You can take the missed dose as soon as you remember. If you remember when it is almost time for your next dose, then skip the missed dose entirely. Do not double your dose to catch up for missed doses.
If you are not regular with your meals, you may experience symptoms of low blood sugar: Such as palpitation, sweating, dizziness, light headedness etc. In this case, taking sugar can relieve your symptoms.
Using this drug may cause edema (swelling) of the ankles. It may also cause swelling in the lungs, which may lead to breathlessness.
Can this drug be used in the treatment of Poly Cystic Ovarian Disease?
This drug belongs to a class of drugs known as sulfonylureas. These drugs are used in the treatment and management of diabetes.
It is safe to take these medications together, if your physician has recommended it. However, it is important to be even more careful about your meals and dosing schedule, to lower the risk of low blood sugar.
If your physician has recommended adding insulin to your treatment, then it should be taken along with this drug. Please make sure that you do not change the prescribed doses in any way, since this may cause changes in blood sugar levels.
Metformin belongs to a different class of drugs, and it can be used along with this drug to improve blood sugar levels. It is safe to take metformin along with this drug, only if your doctor recommends it, and keeping the necessary precautions in mind.
This is a possible side effect, but can be avoided if meals are taken regularly.
No. This drug is not recommended for use in pregnancy. Please consult your doctor before using it during pregnancy.
No. The use of this medication is not recommended for use during lactation. Please consult your doctor before using this drug during breast feeding.
This medicine is not recommended for use in kidney problems because it can further worsen the condition. Please consult your doctor for further assistance.
Glimepiride is advised to use cautiously in patients with liver disease. Your doctor may carefully alter the doses if you suffer from it.
This medicine should not be skipped as it can worsen your diabetes. If however, this medication is missed, take the missed pill as soon as you remember but do not double the dose. Complete the full course as recommended by your doctor.
Avoid using this drug if you are allergic to sulfonylureas or sulfonamides.
Certain blood pressure medicines may increase the effect of glimepiride and cause the blood sugar levels to fall even more causing hypoglycemia. For this reason, you must consult your doctor before starting therapy with this drug along with any hypertension medicines.
Please consult your doctor before taking this medicne.
Research suggests that this medicine should be avoided by women who are breastfeeding.
Please avoid driving when taking this medicine as it may affect your ability to drive.
Please avoid consuming alcohol when taking this medicine.
Regular monitoring for cardiac failure is important.
Research suggests that this medication should be avoided by pregnant women.
Research suggests this medication should be avoided by women who are breastfeeding.
Please avoid driving when taking this medicine as it may affect your ability to drive.
Please avoid consuming alcohol when taking this medicine.
Please regularly monitor blood glucose levels.

Pioglitazone + Glimepiride

Indication

It is indicated for treating Diabetes Mellitus type 2 as monotherapy with Glimepride.

Dosage

Strength: 15mg/2mg

Form: tablet

Dosing interval: 24 Hr

Maximum Dose: Not to exceed 45mg for pioglitazone and 8mg for Glimepiride as per studies conducted.

Maintainance dose

30mg Pioglitazone with 2 mg Glimepiride or 4mg of glimepiride is recommended per day for patients.

Hepatic Adjustment

It is suggested to start with glimepiride alone as 1mg before initating the combination therapy. Also closely monitor Liver Alanine transferase (ALT) values; if less then 2.5 (x Upper limit)it is advised to use with caution. if greater than 2.5 (x Upper limit) it is advised to not to start the combination therapy.

Renal Adjustment

It is suggested to conduct levels of creatinine clearence; if found to be lesser than 22ml/min, start with 1mg per day before starting combination therapy. If Creatinine clearence is greater than 22ml/min it is advised to start with 30mg of pioglitazone and 2 mg of Glimepiride or 4mg Glimepiride once daily.

  • pregnant

    Pregnancy

    Can be used but doctor consultation is important before use, as human and animal research is insufficient or animals showed defects and human research hasn?t been conducted.

  • mother

    Lactation

    It is not suggested in nursing women because of insufficient data known.

ContraIndication
Cautions

BLACK BOX WARNING: Pioglitazone and Rosiglitazone are known to cause an exaggeration of cardiovascular cases. It is suggested to monitor closely in patients with congestive heart failure events because of extreme case of fatality. Edema, weight gain along with cancers such as genitourinary tract cancers have also been reported, so closely monitor before initiating the treatment.

Pharmacokinetics

Disclaimer

Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.

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