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Glibenclamide + Metformin

Indication

It is primarily indicated for treating Diabetes Mellitus type 2.

Mechanism of Action

It is known to Increase the B cell insulin secretion of the pancreas. It enhances insulin sensitivity and basal insulin secretions. Its short acting and more potent

Dosage

Strength: 2.5mg/500mg

Form: tablet

Dosing interval: 24 hr or 12 Hr

Maximum Dose: It is advised to not exceed 20/2000mg per day

Dialyzable:Metformin is dialyzable only

Maintainance dose

The recommended dose as per suggested studies is 1.25/250mg once daily or every 12 hourly, observe the effects then modify after a gap of 14 days.

Hepatic Adjustment

Data suggests reports of lactic acidosis. Not recommended as per experts

Renal Adjustment

It is suggested to determine eGFR (estimated glomerular filteration rate ), if found to be less than 30ml/min/1.73m2, contraindication reported. If between 30-45ml/min/1.73m2, not recommended to start a treatment..

  • pregnant

    Pregnancy

    Research on animals showed no effect and no human research was conducted. Or Research on animals have shown some degree of effect but human research did not show any effects.

  • mother

    Lactation

    Insufficient data to prove if the drug enters breast milk, hence not recommended.

ContraIndication
Cautions

Estimate eGFR (estimated glomerular filteration rate) prior to initate treatment. In patients with eGFR less than 30ml/min/1.73m2 the combination is contraindicated. Skin allergies or severe hypoglycemia condition do not favour the therapy unless treated.

Pharmacokinetics

Disclaimer

Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.

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