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It is primarily indicated for treating Diabetes Mellitus type 2. It has also reported activity against cancerous cells.
It is dependent upon the presence of Insulin for its action. It controls the transcription mechanism of insulin sensitive genes for lipid and glucose metabolism in lipidic, liver and tissues of muscles.
Dosing interval: 21 Hr
Maximum Dose: 45mg per day
It is suggested to be 15-30mg per day (without Congestive Heart Faliure state) and 15mg per day (with Congestive Heart Faliure state).
Monitor closely ALT levels and bilirubin levels 3 times greater than normal
Study suggests to continue giving prescribed doses as no renal adjustments are required in patients with kidney impairments.
No data known
The medicine is instructed to be used with caution. Risk for neonates and infants not found
BLACK BOX WARNING: Pioglitazone and Rosiglitazone are known to cause an exaggeration of cardiovascular cases. It is suggested to carefully monitor liver ALT (Alanine transferase) levels prior to initate treatment. It is also advised to reduce doses of insulin to 20% when given with Pioglitazone
Time of onset: Delayed
Tmax: 0.63 Liters per kg
Protein Binding : 99%
Elimination Half Life (t1/2): 3-7 hr
Metabolism: The molecule has found to be extensively metabolized by liver
Volume of Distribution (Vd): 0.63 Liters per kg
Hydroxy and keto active derivatives
Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.
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