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Pioglitazone C19H20N2O3S

Molecular Weight: 356g/mol
Dissociation Constant: 5.19
Indication

It is primarily indicated for treating Diabetes Mellitus type 2. It has also reported activity against cancerous cells.

Mechanism of Action

It is dependent upon the presence of Insulin for its action. It controls the transcription mechanism of insulin sensitive genes for lipid and glucose metabolism in lipidic, liver and tissues of muscles.

Dosage

Strength: 45mg

Form: tablet

Dosing interval: 21 Hr

Maximum Dose: 45mg per day

Maintainance dose

It is suggested to be 15-30mg per day (without Congestive Heart Faliure state) and 15mg per day (with Congestive Heart Faliure state).

Hepatic Adjustment

Monitor closely ALT levels and bilirubin levels 3 times greater than normal

Renal Adjustment

Study suggests to continue giving prescribed doses as no renal adjustments are required in patients with kidney impairments.

  • pregnant

    Pregnancy

    No data known

  • mother

    Lactation

    The medicine is instructed to be used with caution. Risk for neonates and infants not found

ContraIndication
Cautions

BLACK BOX WARNING: Pioglitazone and Rosiglitazone are known to cause an exaggeration of cardiovascular cases. It is suggested to carefully monitor liver ALT (Alanine transferase) levels prior to initate treatment. It is also advised to reduce doses of insulin to 20% when given with Pioglitazone

Pharmacokinetics

Time of onset: Delayed

Tmax: 0.63 Liters per kg

Bioavailability: 83%

Protein Binding : 99%

Elimination Half Life (t1/2): 3-7 hr

Metabolism: The molecule has found to be extensively metabolized by liver

Volume of Distribution (Vd): 0.63 Liters per kg

Metabolites:

Hydroxy and keto active derivatives

Disclaimer

Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.

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