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Glimepiride C24H34N4O5S

Molecular Weight: 491g/mol
Dissociation Constant: 3.5
Indication

It is primarily indicated for treating Diabetes Mellitus type 2.

Mechanism of Action

It Increases B cell insulin secretion, receptors and sensitivity. It also decreases the liver production of glucose

Dosage

Strength: 1mg

Form: tablet

Dosing interval: 24 Hr

Maximum Dose: 8mg per day is well tolerated in many patients.

Dialyzable:Caution

Maintainance dose

It is suggested to start with 1-2mg initially, exceeding the doses to upto to 8mg per day

Hepatic Adjustment

It is advised to monitor closely if the patient is having liver insufficiencies.

Renal Adjustment

Evidence suggests that a dose of 1mg per day based on blood glucose level must be prescribed to patients with kidney impairment.

  • pregnant

    Pregnancy

    Can be used but doctor consultation is important before use, as human and animal research is insufficient or animals showed defects and human research hasn?t been conducted.

  • mother

    Lactation

    Insufficient data to prove if the drug enters breast milk, hence not recommended.

ContraIndication
Cautions

Kidney and liver insufficiency patients must be closely observed while taking Gliclazide, Any condition that causes stress and injury may create worsening conditions and patients have to withdraw or discontinue the therapy as well. Alcohol consumption may exaggerate the condition by causing intolerance reactions, close vigilance is suggested. Patients on alcohol should take extreme care because of their risk to develop glucose intolerance.

Pharmacokinetics

Time of onset: 1 Hr

Tmax: 9 Liters

Bioavailability: 100%

Protein Binding : 99.5%

Elimination Half Life (t1/2): 4 Hr (Mean)

Metabolism: The molecule has found to be extensively metabolized by liver

Volume of Distribution (Vd): 9 Liters

Metabolites:

Active: Cyclohexyl hydroxy methyl derivative

Disclaimer

Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.

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