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Rs. 172.13
Rs 202.50


7 tablet(s)/Strip

Pack Size : 4x7's tablet

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Prescription Required

Inosita Plus 50/1000mg 50mg/1000mg tablet

Inosita Plus 50/1000mg 50mg/1000mg tablet is composed of

Sitagliptin (50mg)
Metformin (1000mg)

Primarily used for

Type 2 diabetes

Belongs to the category

Hypoglycaemic excluding Insulin


Please use this medicine cautiously in the elderly.

Assess risk factors for lactic acidosis (buildup of lactate causing acidic pH of blood stream). Discontinue immediately if metabolic acidosis (overproduction of acid in the body) is suspected. Monitor renal (kidney) function at least annually. Discontinue the medicine for 48 hours before and after the elective surgery. 

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For Medical Professionals

Sitagliptin + Metformin


It is primarily indicated for treating Diabetes Mellitus type 2 in people who are unable to respond to a monotherapy with either of the antidiabetic agent.


Strength: 50mg/1000mg

Form: tablet

Dosing interval: 24 Hr

Maximum Dose: Metformin dose not to be exceeded 2000mg per day. Sitagliptin dose not to be exceeded 100mg per day for both therapies

Dialyzable:Metformin: Yes

Maintainance dose

Patients on metformin alone should take sitagliptin 100mg/day with prescribed dose of metformin. Patients alone on sitagliptin therapy should take metformin 1000mg per day plus 100mg per day of sitagliptin.

Hepatic Adjustment

Study found it to be inappropriate to be used in hepatic impairments

Renal Adjustment

In patients with eGFR (glomerular filteration rates less than30ml/min/1.73m2 it is contraindicated. However, in patients eGFR 30-45ml/min/1.73m2 the drug is not recommended.

  • pregnant


    Research on animals showed no effect and no human research was conducted. Or research on animals have shown some degree of effect but human research did not show any effects.

  • mother


    Study insufficient to conclude whether drugs enter breast milk, so the patients must use with caution.


In patients who have reported angioedema should be closely monitered. As per studies, in metabolic acidosis and diabetic ketoacidosis patients close care of therapy is recommended. Evidences of acute pancreatitis with hemorrhage have been reported. In elderly patients with age greater than 80 years close monitoring of therapy is recommended as per studies with inadequate renal functioning.


usesUses of Sitagliptin

Monotherapy: This medicine is used for treating type 2 diabetes (condition characterized by elevated glucose levels) that is inadequately controlled by metformin, diet and exercise.

Dual therapy: It is used for treating diabetes type 2 along with metformin or a glitazone when patients respond inadequately to diet changes, exercise and either metformin or glitazine, or in combination with sulphonylureas in patients contraindicated for metformin, and for patients that do not respond adequately to sulphonylureas alone.

Triple therapy: This medicine is used with metformin and a sulphonylureas or glitazone for treating diabetes 2 that is inadequately controlled by dual therapy.

With insulin: This medicine is used with or without metformin for treating type 2 diabetes in patients who respond inadequately to diet, exercise, and insulin.

side-effectsSide effects of Sitagliptin

The patients administered with this medicine may experience pancreatitis (inflammation of pancreas), allergic reactions, Stevens-Jhonson Syndrome (allergic reaction), Hypoglycemia (low glucose levels), bullous pemphigoid (large fluid-filled blisters), osteoarthritis (weak bones), upper respiratory tract infections, flatulence, swelling, and influenza (flu-like symptoms). 

pillsWhen not to use Sitagliptin

The patients with diabetic ketoacidosis (condition causing fat breakdown at an abnormal rate) and moderate to severe renal (kidney) impairment should avoid use of this medicine.

food-pillsHow to take Sitagliptin

This medicine should be taken with food.

usesUses of Metformin

This medicine is indicated in maturity onset diabetes either alone or with sulphonylureas. It is also used as adjuvant therapy in insulin dependent diabetes, particularly in obese patients.

side-effectsSide effects of Metformin

GI upset, taste disturbance, abnormal liver function tests, hepatitis (inflammatory condition of liver), skin reactions, reduced B12 absorption are some of its side effects. Rarely it may cause lactic acidosis (buildup of lactate causing acidic pH of blood stream).

pillsWhen not to use Metformin

This medicine is contraindicated in patients with diabetic ketoacidosis (life threatening condition in which liver breaks down fats into ketones for energy) or precoma (a state of near unconsciousness), renal (kidney) or hepatic (liver) impairment, acute conditions predisposing to renal impairment, cardiac or respiratory failure, recent myocardial infarction (heart attack), alcoholism and in patients with administration of iodinated contrast materials.

food-pillsHow to take Metformin

This medicine should be taken with food.

D.N.AHow Inosita Plus 50/1000mg works

Inosita Plus is an oral anti-hyperglycemic medicine which is a combination of 2 drugs; sitagliptin and metformin.

Sitagliptin works by DPP-4 inhibition, which is supposed to exert its activity in patients with type 2 diabetes, by reducing the inactivation of incretin hormones. Concentrations of the active complete hormones are amplified, thereby increasing and lengthening the action of these hormones. Incretin hormones, including GLP-1 and GIP, are secreted by the intestine throughout the day, and levels are increased in response to a meal. These hormones are quickly inhibited by the enzyme, DPP-4. By modifying active incretin levels, it increases release of insulin lowers glucagon levels in the circulation, depending on glucose levels.

Metformin works by increasing glucose tolerance among patients with T2 diabetes, and by reducing both basal and postprandial glucose in plasma. It also lowers hepatic glucose formation, decreases intestinal uptake and increases insulin sensitivity by raising peripheral glucose uptake and consumption.Insulin release remains unaffected while fasting levels and 12-hour plasma insulin levels may decrease.

pills Expert Advice for Sitagliptin

  • Please take this medicine with or without meals.
  • Please consult your prescriber immediately if you experience trouble breathing, persistent abdominal pain, or any other adverse effects.
  • Dosage requires adjustment in case of trauma, surgery, and infection.
  • Please monitor glucose levels throughout use of this medicine.
  • Please ensure you tell your doctor you have diabetes before any surgery, getting medicine, etc.


pills Expert Advice for Metformin

Avoid this medication if:

  • You are allergic to this medicine or its contents 

Consult your doctor if:

  • You are pregnant, planning to have a child, or breastfeeding.
  • If you are avoiding unwanted pregnancy, so that your doctor may suggest a suitable form of birth control. Due to Metformin's effects on ovulation and pregnancy.
  • You have any sort of digestive problems after taking this medicine: Nausea, vomiting, diarrhea, etc.
  • You have a medical history of: Liver diseases, kidney diseases, congestive heart failure, or lung disease.
  • If you are about to undergo any medical or surgical treatment. 
  • If you are about to undergo any CT scan, or X-ray, as it may interact with the dyes used in some pf these procedures.
  • If you have a B12 deficiency, are anemic, or are developing symptoms of anemia, Such as: lethargy, aches and pains,  or a pale appearance to the skin. 

Be careful about:

  • Having your meals on time to maintain blood sugar levels.
  • Taking the medicine timely, in the way that your physician has prescribed (with food), this will help avoid digestive disturbances.
  • Alcohol consumption.
  • Avoiding dehydration in any form.

Q: What family of drugs does this medicine belong to?
Q: Does this medicine contain hormones, or insulin?
Q: Can this drug be used with thyroid medications, and steroids?
Q: What is lactic acidosis and does this medication cause it?
Q: How long should I use this medication for?
Q: Can this medicine cause low blood sugar?
Q: What do I do if I miss a dose?
Q: What will happen if I skip a meal?
Q: Will this medicine make me loose or gain weight?
Q: Can this medication cause any Vitamin deficiency or anemia?
Q: Is it safe to use in patients with liver disease?
Q: Can this medicine cause low blood sugar?
Q: What do I do if I miss a dose?
Q: What will happen if I skip a meal?
Q: Will this medicine make me gain or lose weight?
Q: Can this medicine cause disturbances in sleeping patterns, or stomach problems?


  • drive



    Please avoid driving when taking this medicine as it may affect your ability to drive.

  • wine-bottle



    Please avoid consuming alcohol when taking this medicine.


    Please avoid consuming alcohol when taking this medicine.

  • pregnant



    This medicine is not recommended for pregnant females.



    This medicine is safe to use in pregnant females. No evidence of risk found. 

  • mother

    Breast Feeding


    This medicine is not recommended for lactating females.


    This medicine is contraindicated in lactating females.

What side-effects did you experience while using this medicine?

How did you take this medicine?

With food


With or without food


Empty Stomach


How much was the improvement?











What are you using this medicine for?

Type 2 diabetes




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