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Rs. 212.50
Rs 250.00

Rs.30.36/tablet

7 tablet(s)/Strip

Pack Size : 2x7's tablet

Rs.500 Total

Jentin 100mg tablet

Jentin 100mg tablet is composed of

Sitagliptin (100mg)

Primarily used for

Type 2 diabetes

Belongs to the category

Hypoglycemics

Precaution:

Please use this medicine cautiously in the elderly.

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For Medical Professionals
First
Second
Third

Sitagliptin C16H15F6N5O

Molecular Weight: 407g/mol
Dissociation Constant: 8.78
Indication

It is primarily indicated for treating Diabetes Mellitus type 2.

Mechanism of Action

It is a pyrazine derived dipeptidyl peptidase 4 Inhibtor that stops the activity of hormone Incretin which is responsible for releasing insulin and reducing glucagon release from pancreatic cells. It may also cause inflammation in pancreas.

Dosage

Strength: 100mg

Form: tablet

Dosing interval: 24 Hr

Maximum Dose: Maximum recommended dose for sitagliptin is 100mg

Dialyzable:Yes

Maintainance dose

100mg once a day

Hepatic Adjustment

The medicine does not require any dose adjustments in mild to moderate hepatic insufficiency

Renal Adjustment

Data based study suggests in patients with creatinine clearence 30-50ml/min initaite 50mg once daily. In patients with creatinine clearence less than 50ml/min, 25mg Once daily. Also, 25mg per day for patients with end-stage renal disease or peritoneal dialysis.

  • pregnant

    Pregnancy

    Research on animals showed no effect and no human research was conducted. Or research on animals have shown some degree of effect but human research did not show any effects.

  • mother

    Lactation

    Study suggests to be used with caution. Risk for neonates and infants not known.

ContraIndication
Cautions

End stage renal diseased patients should be closely monitored. Dermatologic conditions for eg. Blister formation (Bullous pemphigoid) should be taken in care. Pancreatic Hemorrhage or acute inflammatory conditions must be immediately reported. Angioedemic patients.

Pharmacokinetics

Tmax: 198 Liters

Bioavailability: 87%

Protein Binding : 38%

Elimination Half Life (t1/2): 12 Hr

Metabolism: The molecule has found to have a limited metabolism through liver

Volume of Distribution (Vd): 198 Liters

Metabolites:

Sitagliptin is known to not undergo extensive metabolism as per studies, so no metabolites identified.

usesUses of Jentin

Monotherapy: This medicine is used for treating type 2 diabetes (condition characterized by elevated glucose levels) that is inadequately controlled by metformin, diet and exercise.

Dual therapy: It is used for treating diabetes type 2 along with metformin or a glitazone when patients respond inadequately to diet changes, exercise and either metformin or glitazine, or in combination with sulphonylureas in patients contraindicated for metformin, and for patients that do not respond adequately to sulphonylureas alone.

Triple therapy: This medicine is used with metformin and a sulphonylureas or glitazone for treating diabetes 2 that is inadequately controlled by dual therapy.

With insulin: This medicine is used with or without metformin for treating type 2 diabetes in patients who respond inadequately to diet, exercise, and insulin.

side-effectsSide effects of Jentin

The patients administered with this medicine may experience pancreatitis (inflammation of pancreas), allergic reactions, Stevens-Jhonson Syndrome (allergic reaction), Hypoglycemia (low glucose levels), bullous pemphigoid (large fluid-filled blisters), osteoarthritis (weak bones), upper respiratory tract infections, flatulence, swelling, and influenza (flu-like symptoms). 

pillsWhen not to use Jentin

The patients with diabetic ketoacidosis (condition causing fat breakdown at an abnormal rate) and moderate to severe renal (kidney) impairment should avoid use of this medicine.

food-pillsHow to take Jentin

This medicine should be taken with food.

pills Expert Advice for Jentin

  • Please take this medicine with or without meals.
  • Please consult your prescriber immediately if you experience trouble breathing, persistent abdominal pain, or any other adverse effects.
  • Dosage requires adjustment in case of trauma, surgery, and infection.
  • Please monitor glucose levels throughout use of this medicine.
  • Please ensure you tell your doctor you have diabetes before any surgery, getting medicine, etc.

 

Q: Can this medicine cause low blood sugar?
Q: What do I do if I miss a dose?
Q: What will happen if I skip a meal?
Q: Will this medicine make me gain or lose weight?
Q: Can this medicine cause disturbances in sleeping patterns, or stomach problems?

Warnings

  • drive

    Driving

    Please avoid driving when taking this medicine as it may affect your ability to drive.

  • wine-bottle

    Alcohol

    Please avoid consuming alcohol when taking this medicine.

  • pregnant

    Pregnancy

    This medicine is not recommended for pregnant females.

     

  • mother

    Breast Feeding

    This medicine is not recommended for lactating females.

What side-effects did you experience while using this medicine?

How did you take this medicine?

With food


100%

With or without food


0%

Empty Stomach


0%

How much was the improvement?

1


0%

2


0%

3


100%

4


0%

5


0%

What are you using this medicine for?

Type 2 diabetes


100%

Others


0%

Number of survey's Available: 1