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This medication is used for managing non-insulin dependent diabetes

Some patients might experience hypoglycemia and liver failure. Please consult your doctor if you experience any of these symptoms.

Please consult your doctor before taking this medication if you have any of these conditions; insulin-dependent diabetes mellitus (type of diabetes), or diabetic Ketoacidosis (diabetic complication).

This medicine should be taken with food.

Avoid this medication if:

  • You are allergic to this medicine or it's contents (Sulfa, etc.)

Consult your doctor if:

  • You are pregnant, planning to have a child, or breastfeeding.
  • You have any sort of digestive problems.
  • You have a medical history of: Liver diseases, kidney diseases, thyroid problems, blood disorders, etc.
  • Inform your physician about any other medication you are taking. Especially NSAIDs, thyroid medicines or blood pressure medications (such as Beta Blockers, or ACE inhibitors.)

Be careful about:

  • Having your meals on time to maintain blood sugar levels
  • Taking the medicine timely, in the way that your physician has prescribed (with food)
  • Following the lifestyle changes that your physician has suggested.
  • Alcohol consumption should be avoided.
Type II Diabetes
This drug belongs to a class of drugs known as sulfonylureas. These drugs are used in the treatment and management of diabetes.
It is safe to take these medications together, if your physician has recommended it. However, it is important to be even more careful about your meals and dosing schedule, to lower the risk of low blood sugar.
If your physician has recommended adding insulin to your treatment, then it should be taken along with this drug. Please make sure that you do not change the prescribed doses in any way, since this may cause changes in blood sugar levels.
Metformin belongs to a different class of drugs, and it can be used along with this drug to improve blood sugar levels. It is safe to take metformin along with this drug, only if your doctor recommends it, and keeping the necessary precautions in mind.
This is a possible side effect, but can be avoided if meals are taken regularly.
No. This drug is not recommended for use in pregnancy. Please consult your doctor before using it during pregnancy.
No. The use of this medication is not recommended for use during lactation. Please consult your doctor before using this drug during breast feeding.
This medicine is not recommended for use in kidney problems because it can further worsen the condition. Please consult your doctor for further assistance.
Glimepiride is advised to use cautiously in patients with liver disease. Your doctor may carefully alter the doses if you suffer from it.
This medicine should not be skipped as it can worsen your diabetes. If however, this medication is missed, take the missed pill as soon as you remember but do not double the dose. Complete the full course as recommended by your doctor.
Avoid using this drug if you are allergic to sulfonylureas or sulfonamides.
Certain blood pressure medicines may increase the effect of glimepiride and cause the blood sugar levels to fall even more causing hypoglycemia. For this reason, you must consult your doctor before starting therapy with this drug along with any hypertension medicines.
Research suggests that this medication should be avoided by pregnant women.
Research suggests this medication should be avoided by women who are breastfeeding.
Please avoid driving when taking this medicine as it may affect your ability to drive.
Please avoid consuming alcohol when taking this medicine.
Please regularly monitor blood glucose levels.

Glimepiride C24H34N4O5S

Molecular Weight: 491g/mol
Dissociation Constant: 3.5
Indication

It is primarily indicated for treating Diabetes Mellitus type 2.

Mechanism of Action

It Increases B cell insulin secretion, receptors and sensitivity. It also decreases the liver production of glucose

Dosage

Strength: 4mg

Form: tablet

Dosing interval: 24 Hr

Maximum Dose: 8mg per day is well tolerated in many patients.

Dialyzable:Caution

Maintainance dose

It is suggested to start with 1-2mg initially, exceeding the doses to upto to 8mg per day

Hepatic Adjustment

It is advised to monitor closely if the patient is having liver insufficiencies.

Renal Adjustment

Evidence suggests that a dose of 1mg per day based on blood glucose level must be prescribed to patients with kidney impairment.

  • pregnant

    Pregnancy

    Can be used but doctor consultation is important before use, as human and animal research is insufficient or animals showed defects and human research hasn?t been conducted.

  • mother

    Lactation

    Insufficient data to prove if the drug enters breast milk, hence not recommended.

ContraIndication
Cautions

Kidney and liver insufficiency patients must be closely observed while taking Gliclazide, Any condition that causes stress and injury may create worsening conditions and patients have to withdraw or discontinue the therapy as well. Alcohol consumption may exaggerate the condition by causing intolerance reactions, close vigilance is suggested. Patients on alcohol should take extreme care because of their risk to develop glucose intolerance.

Pharmacokinetics

Time of onset: 1 Hr

Tmax: 9 Liters

Bioavailability: 100%

Protein Binding : 99.5%

Elimination Half Life (t1/2): 4 Hr (Mean)

Metabolism: The molecule has found to be extensively metabolized by liver

Volume of Distribution (Vd): 9 Liters

Metabolites:

Active: Cyclohexyl hydroxy methyl derivative

Disclaimer

Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.

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