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Repaglinide C27H36N2O4

Molecular Weight: 452g/mol
Dissociation Constant: 5.9
Indication

Indicated for treating Diabetes Mellitus type 2.

Mechanism of Action

Repaglinide antagonizes potassium channel on B cells of pancreas increasing Ca influx through potassium ATPase pump causing release of insulin.

Dosage

Strength: 2mg

Form: tablet

Dosing interval: 8-12 hr

Maximum Dose: 4mg/ dose OR 16mg per Day. Maximum 6mg/dose when prescribed with cyclosporine (Monitoring required).

Dialyzable:The drug is reported to be dialysed using hemodialysis procedure as per studies.

Maintainance dose

If glucose levels (HbA1C) less 8%: A dose of 0.5mg two to four times a day is suggested ;Whereas if glucose levels (HbA1C) above 8%: A starting dose of 1-2mg two to four times a day then double the doses at 1 week interval for adjustment purpose.

Hepatic Adjustment

Make a gap of more than 1 week when initiating therapy for usual dose response and monitor

Renal Adjustment

Evidence based study suggests that in patients with Creatinine Clearence 20-40ml/min initiate a dose of 0.5mg with meals, then titrate accordingly.

  • pregnant

    Pregnancy

    Can be used but doctor consultation is important before use, as human and animal research is insufficient or animals showed defects and human research hasn?t been conducted.

  • mother

    Lactation

    Research suggests that this medicine should not br used in nursing mothers.

ContraIndication
Cautions

Study suggests to monitor closely when prescribed with cyclosporine. Stress/traumatic conditions. Prescribe with care if patient has a history of Cardiovascular events.

Pharmacokinetics

Time of onset: 15-1 hour

Tmax: 31 Liters

Bioavailability: 56%

Protein Binding : more than 98%

Elimination Half Life (t1/2): 1 Hr

Metabolism: The molecule has found to be extensively metabolized by liver

Volume of Distribution (Vd): 31 Liters

Metabolites:

Active: Oxidized dicarboxylic acid, aromatic amine

Disclaimer

Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.

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