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Rs.7.65/Pack
Rs 9.00

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Pack Size : 3x10's tablet

Rs.9 Total

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Prescription Required

Novirep 1mg 1mg tablet

Novirep 1mg 1mg tablet is composed of

Repaglinide (1mg)

Primarily used for

Type 2 diabetes

Belongs to the category

Hypoglycaemic excluding Insulin

Precaution:

It is important to occasionally check blood glucose levels and glycosylated hemoglobin (HbA1c blood test) to ensure that treatment is working and blood glucose levels are in the normal range.

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For Medical Professionals
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Repaglinide C27H36N2O4

Molecular Weight: 452g/mol
Dissociation Constant: 5.9
Indication

Indicated for treating Diabetes Mellitus type 2.

Mechanism of Action

Repaglinide antagonizes potassium channel on B cells of pancreas increasing Ca influx through potassium ATPase pump causing release of insulin.

Dosage

Strength: 1mg

Form: tablet

Dosing interval: 8-12 hr

Maximum Dose: 4mg/ dose OR 16mg per Day. Maximum 6mg/dose when prescribed with cyclosporine (Monitoring required).

Dialyzable:The drug is reported to be dialysed using hemodialysis procedure as per studies.

Maintainance dose

If glucose levels (HbA1C) less 8%: A dose of 0.5mg two to four times a day is suggested ;Whereas if glucose levels (HbA1C) above 8%: A starting dose of 1-2mg two to four times a day then double the doses at 1 week interval for adjustment purpose.

Hepatic Adjustment

Make a gap of more than 1 week when initiating therapy for usual dose response and monitor

Renal Adjustment

Evidence based study suggests that in patients with Creatinine Clearence 20-40ml/min initiate a dose of 0.5mg with meals, then titrate accordingly.

  • pregnant

    Pregnancy

    Can be used but doctor consultation is important before use, as human and animal research is insufficient or animals showed defects and human research hasn?t been conducted.

  • mother

    Lactation

    Research suggests that this medicine should not br used in nursing mothers.

ContraIndication
Cautions

Study suggests to monitor closely when prescribed with cyclosporine. Stress/traumatic conditions. Prescribe with care if patient has a history of Cardiovascular events.

Pharmacokinetics

Time of onset: 15-1 hour

Tmax: 31 Liters

Bioavailability: 56%

Protein Binding : more than 98%

Elimination Half Life (t1/2): 1 Hr

Metabolism: The molecule has found to be extensively metabolized by liver

Volume of Distribution (Vd): 31 Liters

Metabolites:

Active: Oxidized dicarboxylic acid, aromatic amine

usesUses of Novirep 1mg

This medicine is usually prescribed to type 2 diabetes patients who are unable to control their blood glucose levels with just exercise and diet. Patients who are unable to control their blood glucose levels with just metformin are also prescribed this medicine.

side-effectsSide effects of Novirep 1mg

Some patients might experience hypoglycemia (low blood glucose), visual disturbances, upset stomach, and rash. Please consult your doctor if you experience any of these symptoms.

pillsWhen not to use Novirep 1mg

Please consult your doctor before taking this medicine if you have any of these conditions; type 1 diabetes, diabetic ketoacidosis (diabetes complication), renal or hepatic insufficiency (kidney or liver disorder).

food-pillsHow to take Novirep 1mg

This medicine should not be taken with food

D.N.AHow Novirep 1mg works

Repaglinide is an oral diabetes medicine that helps control blood sugar levels by helping your pancreas release more insulin.

pills Expert Advice for Novirep 1mg

Avoid this medication if:

  • You are allergic to this medicine or its contents.

Consult your doctor if:

  • You are pregnant, planning to have a child, or breastfeeding.
  • You have a medical history of: Liver or kidney diseases.
  • You are about to undergo any dental or surgical procedure.
  • You are taking any other medication.
  • You develop joint pain, as this is a possible side effect of this medication.
  • You experience weight gain, as this is a possible side effect of this medication.
  • You are taking NPH Insulin along with this drug, as it can interfere with this drugs effects.

Be careful about:

  • Having your meals on time to maintain blood sugar levels
  • Taking the medicine timely, in the way that your physician has prescribed (it is usually suggested that this medicine is taken close to mealtimes.)
  • possible weight gain

Q: Can this medicine cause low blood sugar?
Q: What do I do if I miss a dose?
Q: What will happen if I skip a meal?
Q: Will this medicine make me gain weight?
Q: Should this medicine be used beyond the date of expiry?
Q: To which class of drugs does repaglinide belong?
Q: What do I use repaglinide for?
Q: What is the safety of replaginide?

Warnings

  • drive

    Driving

    Please avoid driving when taking this medicine as it may affect your ability to drive.

  • wine-bottle

    Alcohol

    Please avoid consuming alcohol when taking this medicine.

  • pregnant

    Pregnancy

    Please consult your doctor before taking this medicine.

  • mother

    Breast Feeding

    Research suggests that this medicine should be avoided by women who are breastfeeding.

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