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Prescription Required
Indicated for treating Diabetes Mellitus type 2.
Repaglinide antagonizes potassium channel on B cells of pancreas increasing Ca influx through potassium ATPase pump causing release of insulin.
Strength: 1mg
Form: tablet
Dosing interval: 8-12 hr
Maximum Dose: 4mg/ dose OR 16mg per Day. Maximum 6mg/dose when prescribed with cyclosporine (Monitoring required).
Dialyzable:The drug is reported to be dialysed using hemodialysis procedure as per studies.
If glucose levels (HbA1C) less 8%: A dose of 0.5mg two to four times a day is suggested ;Whereas if glucose levels (HbA1C) above 8%: A starting dose of 1-2mg two to four times a day then double the doses at 1 week interval for adjustment purpose.
Make a gap of more than 1 week when initiating therapy for usual dose response and monitor
Evidence based study suggests that in patients with Creatinine Clearence 20-40ml/min initiate a dose of 0.5mg with meals, then titrate accordingly.
Can be used but doctor consultation is important before use, as human and animal research is insufficient or animals showed defects and human research hasn?t been conducted.
Research suggests that this medicine should not br used in nursing mothers.
Study suggests to monitor closely when prescribed with cyclosporine. Stress/traumatic conditions. Prescribe with care if patient has a history of Cardiovascular events.
Time of onset: 15-1 hour
Tmax: 31 Liters
Bioavailability: 56%
Protein Binding : more than 98%
Elimination Half Life (t1/2): 1 Hr
Metabolism: The molecule has found to be extensively metabolized by liver
Volume of Distribution (Vd): 31 Liters
Active: Oxidized dicarboxylic acid, aromatic amine
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