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This medicine is usually prescribed to type 2 diabetes patients who are unable to control their blood glucose levels with just exercise and diet. Patients who are unable to control their blood glucose levels with just metformin are also prescribed this medicine.

Some patients might experience hypoglycemia (low blood glucose), visual disturbances, upset stomach, and rash. Please consult your doctor if you experience any of these symptoms.

Please consult your doctor before taking this medicine if you have any of these conditions; type 1 diabetes, diabetic ketoacidosis (diabetes complication), renal or hepatic insufficiency (kidney or liver disorder).

This medicine should not be taken with food.

Avoid this medication if:

  • You are allergic to this medicine or its contents.

Consult your doctor if:

  • You are pregnant, planning to have a child, or breastfeeding.
  • You have a medical history of: Liver or kidney diseases.
  • You are about to undergo any dental or surgical procedure.
  • You are taking any other medication.
  • You develop joint pain, as this is a possible side effect of this medication.
  • You experience weight gain, as this is a possible side effect of this medication.
  • You are taking NPH Insulin along with this drug, as it can interfere with this drugs effects.

Be careful about:

  • Having your meals on time to maintain blood sugar levels
  • Taking the medicine timely, in the way that your physician has prescribed (it is usually suggested that this medicine is taken close to mealtimes.)
  • possible weight gain
Type II diabetes
This is a possible side effect, but can be avoided if meals are taken regularly. Try to carry sugar or a sugary drink in case you experience lightheadedness, or any other symptoms of low blood sugar. Take extra precautions during times of stress, or dehydration (fever, diarrhea etc.)
You can take the missed dose as soon as you remember. If you remember when it is almost time for your next dose, then skip the missed dose entirely. Do not double your dose to catch up for missed doses.
If you are not regular with your meals, you may experience symptoms of low blood sugar: Such as palpitation, sweating, dizziness, light headedness etc. In this case, taking sugar can relieve your symptoms.
Weight gain is a possible side effect, kindly consult your physician if it occurs.
Kindly avoid taking any medication beyond the mentioned date of expiry.
It is an insulin secreting, non-sulfonylurea drug that comes under the meglitinide category.
If you are a Type 2 diabetic patient, your pancreas is not making enough insulin and repaglinide is going to help the pancreas make more insulin to remove the excess glucose levels from blood.
It is absolutely safe and side-effects caused are relatively mild when compared to sulfonylurea drugs. Any side-effect felt should be reported to doctor.
Please consult your doctor before taking this medicine.
Research suggests that this medicine should be avoided by women who are breastfeeding.
Please avoid driving when taking this medicine as it may affect your ability to drive.
Please avoid consuming alcohol when taking this medicine.
It is important to occasionally check blood glucose levels and glycosylated hemoglobin (HbA1c blood test) to ensure that treatment is working and blood glucose levels are in the normal range.

Repaglinide C27H36N2O4

Molecular Weight: 452g/mol
Dissociation Constant: 5.9

Indicated for treating Diabetes Mellitus type 2.

Mechanism of Action

Repaglinide antagonizes potassium channel on B cells of pancreas increasing Ca influx through potassium ATPase pump causing release of insulin.


Strength: 1mg

Form: tablet

Dosing interval: 8-12 hr

Maximum Dose: 4mg/ dose OR 16mg per Day. Maximum 6mg/dose when prescribed with cyclosporine (Monitoring required).

Dialyzable:The drug is reported to be dialysed using hemodialysis procedure as per studies.

Maintainance dose

If glucose levels (HbA1C) less 8%: A dose of 0.5mg two to four times a day is suggested ;Whereas if glucose levels (HbA1C) above 8%: A starting dose of 1-2mg two to four times a day then double the doses at 1 week interval for adjustment purpose.

Hepatic Adjustment

Make a gap of more than 1 week when initiating therapy for usual dose response and monitor

Renal Adjustment

Evidence based study suggests that in patients with Creatinine Clearence 20-40ml/min initiate a dose of 0.5mg with meals, then titrate accordingly.

  • pregnant


    Can be used but doctor consultation is important before use, as human and animal research is insufficient or animals showed defects and human research hasn?t been conducted.

  • mother


    Research suggests that this medicine should not br used in nursing mothers.


Study suggests to monitor closely when prescribed with cyclosporine. Stress/traumatic conditions. Prescribe with care if patient has a history of Cardiovascular events.


Time of onset: 15-1 hour

Tmax: 31 Liters

Bioavailability: 56%

Protein Binding : more than 98%

Elimination Half Life (t1/2): 1 Hr

Metabolism: The molecule has found to be extensively metabolized by liver

Volume of Distribution (Vd): 31 Liters


Active: Oxidized dicarboxylic acid, aromatic amine


Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.


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