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This medicine is usually prescribed to type 2 diabetes patients who are unable to control their blood glucose levels with just exercise and diet. Patients who are unable to control their blood glucose levels with just metformin are also prescribed this medicine.
Some patients might experience hypoglycemia (low blood glucose), visual disturbances, upset stomach, and rash. Please consult your doctor if you experience any of these symptoms.
Please consult your doctor before taking this medicine if you have any of these conditions; type 1 diabetes, diabetic ketoacidosis (diabetes complication), renal or hepatic insufficiency (kidney or liver disorder).
Avoid this medication if:
Consult your doctor if:
Be careful about:
Indicated for treating Diabetes Mellitus type 2.
Repaglinide antagonizes potassium channel on B cells of pancreas increasing Ca influx through potassium ATPase pump causing release of insulin.
Dosing interval: 8-12 hr
Maximum Dose: 4mg/ dose OR 16mg per Day. Maximum 6mg/dose when prescribed with cyclosporine (Monitoring required).
Dialyzable:The drug is reported to be dialysed using hemodialysis procedure as per studies.
If glucose levels (HbA1C) less 8%: A dose of 0.5mg two to four times a day is suggested ;Whereas if glucose levels (HbA1C) above 8%: A starting dose of 1-2mg two to four times a day then double the doses at 1 week interval for adjustment purpose.
Make a gap of more than 1 week when initiating therapy for usual dose response and monitor
Evidence based study suggests that in patients with Creatinine Clearence 20-40ml/min initiate a dose of 0.5mg with meals, then titrate accordingly.
Can be used but doctor consultation is important before use, as human and animal research is insufficient or animals showed defects and human research hasn?t been conducted.
Research suggests that this medicine should not br used in nursing mothers.
Study suggests to monitor closely when prescribed with cyclosporine. Stress/traumatic conditions. Prescribe with care if patient has a history of Cardiovascular events.
Time of onset: 15-1 hour
Tmax: 31 Liters
Protein Binding : more than 98%
Elimination Half Life (t1/2): 1 Hr
Metabolism: The molecule has found to be extensively metabolized by liver
Volume of Distribution (Vd): 31 Liters
Active: Oxidized dicarboxylic acid, aromatic amine
Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.
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