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This medicine is used in the management of type 2 diabetes particularly in overweight patients.

Some patients might experience visual disturbance and Respiratory infection. Please consult your doctor if you experience any of these symtpoms

Please consult your doctor before taking this medicine if you have any of these conditions; hepatic impairment, cardiac failure or history of cardiac failure.

This medicine should be taken with food.

Avoid this medication if:

  • You are allergic to this medicine or its contents.

Consult your doctor if:

  • You are pregnant, planning to have a child, or breastfeeding.
  • You have any sort of digestive problems
  • You have a medical history of: Liver diseases, kidney diseases, heart diseases, or bladder cancers.
  • Inform your physician about any other medication you are taking.
  • You experience weakness in your bones
  • You experience breathing difficulties (due to swelling in the lungs)

Be careful about:

  • Having your meals on time to maintain blood sugar levels
  • Taking the medicine timely, in the way that your physician has prescribed.
  • Weight gain, as it is a possible side effect of this medicine.

 

Type II diabetes
It belongs to a class of drugs known as glitazones, or thiazolidinediones
This is a possible side effect, but can be avoided if meals are taken regularly. Try to carry sugar or a sugary drink in case you experience lightheadedness, or any other symptoms of low blood sugar.
You can take the missed dose as soon as you remember. If you remember when it is almost time for your next dose, then skip the missed dose entirely. Do not double your dose to catch up for missed doses.
If you are not regular with your meals, you may experience symptoms of low blood sugar: Such as palpitation, sweating, dizziness, light headedness etc. In this case, taking sugar can relieve your symptoms.
Using this drug may cause edema (swelling) of the ankles. It may also cause swelling in the lungs, which may lead to breathlessness.
Can this drug be used in the treatment of Poly Cystic Ovarian Disease?
Please consult your doctor before taking this medicne.
Research suggests that this medicine should be avoided by women who are breastfeeding.
Please avoid driving when taking this medicine as it may affect your ability to drive.
Please avoid consuming alcohol when taking this medicine.
Regular monitoring for cardiac failure is important.

Pioglitazone C19H20N2O3S

Molecular Weight: 356g/mol
Dissociation Constant: 5.19
Indication

It is primarily indicated for treating Diabetes Mellitus type 2. It has also reported activity against cancerous cells.

Mechanism of Action

It is dependent upon the presence of Insulin for its action. It controls the transcription mechanism of insulin sensitive genes for lipid and glucose metabolism in lipidic, liver and tissues of muscles.

Dosage

Strength: 45mg

Form: tablet

Dosing interval: 21 Hr

Maximum Dose: 45mg per day

Maintainance dose

It is suggested to be 15-30mg per day (without Congestive Heart Faliure state) and 15mg per day (with Congestive Heart Faliure state).

Hepatic Adjustment

Monitor closely ALT levels and bilirubin levels 3 times greater than normal

Renal Adjustment

Study suggests to continue giving prescribed doses as no renal adjustments are required in patients with kidney impairments.

  • pregnant

    Pregnancy

    No data known

  • mother

    Lactation

    The medicine is instructed to be used with caution. Risk for neonates and infants not found

ContraIndication
Cautions

BLACK BOX WARNING: Pioglitazone and Rosiglitazone are known to cause an exaggeration of cardiovascular cases. It is suggested to carefully monitor liver ALT (Alanine transferase) levels prior to initate treatment. It is also advised to reduce doses of insulin to 20% when given with Pioglitazone

Pharmacokinetics

Time of onset: Delayed

Tmax: 0.63 Liters per kg

Bioavailability: 83%

Protein Binding : 99%

Elimination Half Life (t1/2): 3-7 hr

Metabolism: The molecule has found to be extensively metabolized by liver

Volume of Distribution (Vd): 0.63 Liters per kg

Metabolites:

Hydroxy and keto active derivatives

Disclaimer

Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.

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