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It is primarily indicated for treating Diabetes Mellitus type 2.
It is a pyrazine derived dipeptidyl peptidase 4 Inhibtor that stops the activity of hormone Incretin which is responsible for releasing insulin and reducing glucagon release from pancreatic cells. It may also cause inflammation in pancreas.
Dosing interval: 24 Hr
Maximum Dose: Maximum recommended dose for sitagliptin is 100mg
100mg once a day
The medicine does not require any dose adjustments in mild to moderate hepatic insufficiency
Data based study suggests in patients with creatinine clearence 30-50ml/min initaite 50mg once daily. In patients with creatinine clearence less than 50ml/min, 25mg Once daily. Also, 25mg per day for patients with end-stage renal disease or peritoneal dialysis.
Research on animals showed no effect and no human research was conducted. Or research on animals have shown some degree of effect but human research did not show any effects.
Study suggests to be used with caution. Risk for neonates and infants not known.
End stage renal diseased patients should be closely monitored. Dermatologic conditions for eg. Blister formation (Bullous pemphigoid) should be taken in care. Pancreatic Hemorrhage or acute inflammatory conditions must be immediately reported. Angioedemic patients.
Tmax: 198 Liters
Protein Binding : 38%
Elimination Half Life (t1/2): 12 Hr
Metabolism: The molecule has found to have a limited metabolism through liver
Volume of Distribution (Vd): 198 Liters
Sitagliptin is known to not undergo extensive metabolism as per studies, so no metabolites identified.
Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.
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