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Sitagliptin + Metformin

Indication

It is primarily indicated for treating Diabetes Mellitus type 2 in people who are unable to respond to a monotherapy with either of the antidiabetic agent.

Dosage

Strength: 50mg/500mg

Form: tablet

Dosing interval: 24 Hr

Maximum Dose: Metformin dose not to be exceeded 2000mg per day. Sitagliptin dose not to be exceeded 100mg per day for both therapies

Dialyzable:Metformin: Yes

Maintainance dose

Patients on metformin alone should take sitagliptin 100mg/day with prescribed dose of metformin. Patients alone on sitagliptin therapy should take metformin 1000mg per day plus 100mg per day of sitagliptin.

Hepatic Adjustment

Study found it to be inappropriate to be used in hepatic impairments

Renal Adjustment

In patients with eGFR (glomerular filteration rates less than30ml/min/1.73m2 it is contraindicated. However, in patients eGFR 30-45ml/min/1.73m2 the drug is not recommended.

  • pregnant

    Pregnancy

    Research on animals showed no effect and no human research was conducted. Or research on animals have shown some degree of effect but human research did not show any effects.

  • mother

    Lactation

    Study insufficient to conclude whether drugs enter breast milk, so the patients must use with caution.

ContraIndication
Cautions

In patients who have reported angioedema should be closely monitered. As per studies, in metabolic acidosis and diabetic ketoacidosis patients close care of therapy is recommended. Evidences of acute pancreatitis with hemorrhage have been reported. In elderly patients with age greater than 80 years close monitoring of therapy is recommended as per studies with inadequate renal functioning.

Pharmacokinetics

Disclaimer

Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.

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