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Monotherapy: This medicine is used for treating type 2 diabetes (condition characterized by elevated glucose levels) that is inadequately controlled by metformin, diet and exercise.

Dual therapy: It is used for treating diabetes type 2 along with metformin or a glitazone when patients respond inadequately to diet changes, exercise and either metformin or glitazine, or in combination with sulphonylureas in patients contraindicated for metformin, and for patients that do not respond adequately to sulphonylureas alone.

Triple therapy: This medicine is used with metformin and a sulphonylureas or glitazone for treating diabetes 2 that is inadequately controlled by dual therapy.

With insulin: This medicine is used with or without metformin for treating type 2 diabetes in patients who respond inadequately to diet, exercise, and insulin.

The patients administered with this medicine may experience pancreatitis (inflammation of pancreas), allergic reactions, Stevens-Jhonson Syndrome (allergic reaction), Hypoglycemia (low glucose levels), bullous pemphigoid (large fluid-filled blisters), osteoarthritis (weak bones), upper respiratory tract infections, flatulence, swelling, and influenza (flu-like symptoms). 

The patients with diabetic ketoacidosis (condition causing fat breakdown at an abnormal rate) and moderate to severe renal (kidney) impairment should avoid use of this medicine.

  1. What else can I do to manage my glucose levels?

To manage your glucose levels, you can make several lifestyle changes such as:

  • Following a light regular physical exercise routine
  • Limiting use of alcohol
  • Limiting or complete cessation of smoking
  • Eating healthy
  • Taking care of your physical and mental health

 

  1. How does Sitagliptin work?

It works by increasing the amount of insulin your body makes. Insulin in the hormone that is involved in glucose management in your body.

 

  1. How long does Sitagliptin take to work?

It begins working after approximately 2 weeks. However, you will see the maximum effects after 18-20 weeks.

 

 

 

  1. What is the best time to take Sitagliptin?

Take it at one time every day. Please follow this same routine and continue to take it at the same time every day.

 

  1. Does Sitagliptin have any serious side effects?

This medicine does not have any serious side effects when taken according to the doctor’s prescription, at the specified time. However, if you experience any severe side effects, consult your doctor immediately.

This medicine should be taken with food.
  • Please take this medicine with or without meals.
  • Please consult your prescriber immediately if you experience trouble breathing, persistent abdominal pain, or any other adverse effects.
  • Dosage requires adjustment in case of trauma, surgery, and infection.
  • Please monitor glucose levels throughout use of this medicine.
  • Please ensure you tell your doctor you have diabetes before any surgery, getting medicine, etc.

 

Type II diabetes
This is a possible side effect, but can be avoided if meals are taken regularly. Try to carry sugar or a sugary drink in case you experience lightheadedness, or any other symptoms of low blood sugar. Take extra precautions during times of stress, or dehydration (fever, diarrhea etc.)
You can take the missed dose as soon as you remember. If you remember when it is almost time for your next dose, then skip the missed dose entirely. Do not double your dose to catch up for missed doses.
If you are not regular with your meals, you may experience symptoms of low blood sugar: Such as palpitation, sweating, dizziness, light headedness etc. In this case, taking sugar can relieve your symptoms.
Weight gain is less likely with this drug.
It is possible for patients to feel sleepy while taking this drug, and constipation is also a possible side effect.
This medicine is not recommended for pregnant females.  
This medicine is not recommended for lactating females.
Please avoid driving when taking this medicine as it may affect your ability to drive.
Please avoid consuming alcohol when taking this medicine.
Please use this medicine cautiously in the elderly.

Sitagliptin C16H15F6N5O

Molecular Weight: 407g/mol
Dissociation Constant: 8.78
Indication

It is primarily indicated for treating Diabetes Mellitus type 2.

Mechanism of Action

It is a pyrazine derived dipeptidyl peptidase 4 Inhibtor that stops the activity of hormone Incretin which is responsible for releasing insulin and reducing glucagon release from pancreatic cells. It may also cause inflammation in pancreas.

Dosage

Strength: 50mg

Form: tablet

Dosing interval: 24 Hr

Maximum Dose: Maximum recommended dose for sitagliptin is 100mg

Dialyzable:Yes

Maintainance dose

100mg once a day

Hepatic Adjustment

The medicine does not require any dose adjustments in mild to moderate hepatic insufficiency

Renal Adjustment

Data based study suggests in patients with creatinine clearence 30-50ml/min initaite 50mg once daily. In patients with creatinine clearence less than 50ml/min, 25mg Once daily. Also, 25mg per day for patients with end-stage renal disease or peritoneal dialysis.

  • pregnant

    Pregnancy

    Research on animals showed no effect and no human research was conducted. Or research on animals have shown some degree of effect but human research did not show any effects.

  • mother

    Lactation

    Study suggests to be used with caution. Risk for neonates and infants not known.

ContraIndication
Cautions

End stage renal diseased patients should be closely monitored. Dermatologic conditions for eg. Blister formation (Bullous pemphigoid) should be taken in care. Pancreatic Hemorrhage or acute inflammatory conditions must be immediately reported. Angioedemic patients.

Pharmacokinetics

Tmax: 198 Liters

Bioavailability: 87%

Protein Binding : 38%

Elimination Half Life (t1/2): 12 Hr

Metabolism: The molecule has found to have a limited metabolism through liver

Volume of Distribution (Vd): 198 Liters

Metabolites:

Sitagliptin is known to not undergo extensive metabolism as per studies, so no metabolites identified.

Disclaimer

Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.

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