Ceftriaxone, a cephalosporin antibiotic, treats a variety of bacterial infections, including some that are life-threatening or severe, such as E. coli, meningitis or pneumonia. It is ineffective against colds, flu, and other viral infections. Ceftriaxone is also prescribed to keep people from getting infections after some types of surgery. It works by destroying bacteria.
This medication is normally given once or twice daily by injection into a vein or muscle as advised by your doctor. The dosage is determined by your symptoms and treatment response. Unless your doctor tells you otherwise, it is advised to drink plenty of water while taking this medication.
Take this antibiotic at regular intervals for the best results. Take this medicine at the same time(s) each day to help you remember.
Even if your symptoms go away after a few days, keep taking this medicine for the full duration recommended by your doctor. Stopping the drug too soon may cause the infection to recur. If your issue persists or worsens, inform your doctor.
Expert Advice
This medication is to be administered by injection or infusion only.
Contact prescriber if there is burning/swelling/redness/pain at injection or infusion or if there is rash, hives, itching, difficulty in breathing or swallowing, unrelieved diarrhea (watery stools), vaginal drainage or itching, mouth sores, blood, pus or mucus in stools or urine, easy bruising or bleeding, unusual chills or fever.
Watery or bloody stools can occur 2 or more months after therapy and can be serious and require immediate treatment.
Take sufficient amounts of fluids (2-3 liters per day) to maintain hydration, unless restricted by the prescriber.
Primary Uses
Indications
This medicine is indicated in severe respiratory, genitourinary (urinary and genital system), bone, joint, abdominal infections, sepsis (life threatening condition in response to infection) and meningitis (inflammation of meninges).
Side Effects
GI upset, skin reactions, blood dyscrasias (blood disorders) are some of its side effects. It may rarely cause pseudomembranous colitis (inflammation of large intestine due to overgrowth of clostridium difficile bacteria), raised liver enzymes, glucosuria (glucose in urine), oliguria (urine output less than 1mL/kg/h), hematuria (blood in urine), bronchospasm (spasm of airways), phlebitis (inflammation of vein) at injection site, urinary and biliary precipitates, nephrolithiasis (kidney stones), pancreatitis (inflammation of pancreas), haemolytic anemia (red cells are destroyed faster than they are made), positive coombs test (test used to detect antibodies against the surface of red blood cells) etc.
Warnings
Pregnancy
Ceftriaxone may be safe for the treatment of bacterial infections during pregnancy. Only take Ceftriaxone if your doctor recommends it.
Lactation
There is no evidence of risk in lactating females; therefore, caution is advised. Consult your doctor before the use of this medicine.
Driving
Dizziness is one of the possible side effects of Ceftriaxone. Thus, it could have an impact on your driving skills.
Liver
Ceftriaxone can induce liver swelling via raising liver enzyme levels. Hence, due to the potential of liver damage, exercise caution while taking Ceftriaxone.
Kidney
The kidneys filter Ceftriaxone, which is then excreted in the urine. Ceftriaxone should be used with caution if you have any kidney-related medical issues, as it increases the danger of kidney damage.
Alcohol
There is no recognized interaction of Ceftriaxone with alcohol. Before consuming, it is best to see your doctor.
Precautions
Patients with severe renal (kidney) and hepatic (liver) impairment and non severe hypersensitivity to other beta lactams are sensitive to the drug. Do not use it in pregnancy unless absolutely indicated. Full blood count should be monitored during prolonged treatment.
Contraindications
This medicine is contraindicated in patients with hypersensitivity to beta lactam drugs, in premature newborns having less than 41 weeks postmenstrual age; neonates over 41 weeks postmenstrual age with jaundice (a condition characterized by yellow discolouration of the skin, eyes and mucous membranes), hypoalbuminemia (low albumin levels) or acidosis (too much acid in body), concomitant treatment with IV calcium (including total parenteral nutrition containing calcium) in neonates over 41 weeks postmenstrual age - risk of precipitation in lungs and urine. It should not be used in hyperbilirubinemia (high bilirubin levels) neonates.
FAQS
What is ceftriaxone used for?
Cefriaxone is used to treat certain bacterial infections.
What is the contraindication of ceftriaxone?
It is contraindicated in hemolytic anemia (red cells are destroyed faster than they are made), diarrhea due to clostridium difficile bacteria, liver and gallbladder problems.
How long does ceftriaxone injection stays in our system?
The average elimination half-life in healthy adults is 5.8–8.7 hours. In patients with renal impairment, the average elimination half-life increases to 11.4–15.7 hours.
How do you give ceftriaxone injection?
1 gm ceftriaxone is dissolved in 10 ml of water. It is administered directly in vein over a period of 5 minutes.
What type of infections does ceftriaxone treat?
It is used to treat gonorrhea (sexually transmitted disease), pelvic inflammatory disease (infection of female reproductive organs), meningitis (inflammation of meninges outside the brain and spinal cord).
Disclaimer
Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.
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