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Pioglitazone + Glimepiride

Indication

It is indicated for treating Diabetes Mellitus type 2 as monotherapy with Glimepride.

Dosage

Strength: 30mg/2mg

Form: tablet

Dosing interval: 24 Hr

Maximum Dose: Not to exceed 45mg for pioglitazone and 8mg for Glimepiride as per studies conducted.

Maintainance dose

30mg Pioglitazone with 2 mg Glimepiride or 4mg of glimepiride is recommended per day for patients.

Hepatic Adjustment

It is suggested to start with glimepiride alone as 1mg before initating the combination therapy. Also closely monitor Liver Alanine transferase (ALT) values; if less then 2.5 (x Upper limit)it is advised to use with caution. if greater than 2.5 (x Upper limit) it is advised to not to start the combination therapy.

Renal Adjustment

It is suggested to conduct levels of creatinine clearence; if found to be lesser than 22ml/min, start with 1mg per day before starting combination therapy. If Creatinine clearence is greater than 22ml/min it is advised to start with 30mg of pioglitazone and 2 mg of Glimepiride or 4mg Glimepiride once daily.

  • pregnant

    Pregnancy

    Can be used but doctor consultation is important before use, as human and animal research is insufficient or animals showed defects and human research hasn?t been conducted.

  • mother

    Lactation

    It is not suggested in nursing women because of insufficient data known.

ContraIndication
Cautions

BLACK BOX WARNING: Pioglitazone and Rosiglitazone are known to cause an exaggeration of cardiovascular cases. It is suggested to monitor closely in patients with congestive heart failure events because of extreme case of fatality. Edema, weight gain along with cancers such as genitourinary tract cancers have also been reported, so closely monitor before initiating the treatment.

Pharmacokinetics

Disclaimer

Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.

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