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Introduction

Expert Advice

  • Take with or without meals.
  • Inform prescriber if you have any pending surgery before starting this medicine.
  • Do not give this to children.

Primary Uses

Indications

This medication is prescribed for prevention of venous thromboembolism (blood clot that starts in a vein) in patients undergoing elective hip or knee replacement surgery, treatment of DVT (blood clot that forms deep in the body), and pulmonary embolism (blood clot in an artery of lung). It is used as prophylaxis of stroke and systemic embolism (obstruction of artery) in patients with non-valvular atrial fibrillation (irregular heartbeat) and prophylaxis of atherothrombotic events (sudden disruption of atherosclerotic plaque and blood clot formation) following an acute coronary syndrome with increased cardiac biomarkers.

Side Effects

Patients administered with this medicine may experience anemia (low red blood cell count), nausea (feeling like vomiting), headache, dizziness (feeling like sleeping), hypotension (low blood pressure), haematoma (localised bleeding), epistaxis (bleeding from nose), haemoptysis (blood in sputum), gastrointestinal upset, fever, edema (swelling), fatigue, renal (kidney) impairment, and serious skin reactions.

Warnings

Pregnancy

This medicine is contraindicated in pregnant females.

Lactation

This medicine is contraindicated in lactating females.

Precautions

Before using this medication patient should inform the prescriber about any history of renal (kidney) impairment, cirrhosis (healthy liver tissue replaced by scarred tissue), GI ulceration (break in the continuity of GI lining), hypertension (high BP), and bleeding disorders. Lumbar puncture and spinal anesthesia are to be avoided during therapy.

Contraindications

This drug is contraindicated in patients with creatinine clearance <15ml/min, clinically significant active bleeding, liver disease associated with coagulopathy (impaired blood coagulation), and hip fracture surgery.

FAQS

How does this medicine work?

This medicine blocks the activity of certain clotting substances in the blood.

Can this medication be used simultaneously with other anti-coagulants?

Avoid concurrent use of this medication with other anticoagulants because of increased bleeding risk unless benefit outweighs risk.

What should I avoid while taking this medication?

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

What will happen if I overdose on this medicine?

Overdose may cause excessive bleeding, contact your doctor or physician immediately.

What happens if I miss a dose?

If you take this medication 1 time each day: Take the medicine as soon as you remember, and then go back to your regular schedule. Do not take two doses on the same day.

Is it better to take this medicine in the morning or evening?

Evening intake of this medicine leads to prolonged exposure to its concentrations and better matches than morning.

What should I avoid while taking this medicine?

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

Does this medicine work immediately?

This medicine begins to reduce blood clotting within a few hours after the first dose. If you stop taking it, its effect on clotting begins to wear off within 24 hours for most people.

Disclaimer

Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.

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