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Metformin C4H11N5

Molecular Weight: 129g/mol
Dissociation Constant: -0.5
Indication

It is primarily indicated for treating Diabetes Mellitus type 2 and for prevention of diabetes. Orphan: Poly cyctic Ovary Syndrome. The molecule has been known to regulate triglyceride and LDL chloestrol level and has been found to be useful as weight reducing agent.

Mechanism of Action

It is responsible for reducing glucose absorption and enhancing insulin cell sensitivity.

Dosage

Strength: 1gm

Form: tablet

Dosing interval: 8-24 Hr

Maximum Dose: 2550 mg/day is well tolerated.

Dialyzable:Yes

Maintainance dose

Type 2 Non Insulin Dependent Diabetes Mellitus: Immediate Release: 500mg twice daily or 850mg per day then, 500mg three times a day. Extended Release: Glucophage XR: 500mg daily; titrate 500mg daily every week. Poly Cystic Ovary syndrome: 1-2g every day orally

Hepatic Adjustment

Risk of Lactic acidosis; Avoid)

Renal Adjustment

In patients with eGFR (glomerular filteration rates less than30ml/min/1.73m2 it is contraindicated. However, in patients eGFR 30-45ml/min/1.73m2 the therapy is not recommended.

  • pregnant

    Pregnancy

    Research on animals showed no effect and no human research was conducted. Or research on animals have shown some degree of effect but human research did not show any effects.

  • mother

    Lactation

    The medicine has shown studies that it enters mothers milk and hence not recommended.

ContraIndication
Cautions

Lactic Acidosis (black Box Warning). May cause ovulation in premenopausal women. May impair B12 and Ca absorption (monitor closely).

Pharmacokinetics

Time of onset: It is known to produce the action within 1-3 hours of administration as per researches conducted.

Tmax: For immediate release tablets the volume of distribution is known to be 650 Liters

Bioavailability: 50-60% (fasting condition)

Protein Binding : It is least bound to protein after administration as per studies.

Elimination Half Life (t1/2): 6 Hr

Metabolism: Not by Liver

Volume of Distribution (Vd): For immediate release tablets the volume of distribution is known to be 650 Liters

Metabolites:

There has not been any metabolites identified as it is reported that metformin is not metabolized.

Disclaimer

Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.

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