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This medicine is used in the treatment of depressive illness.

The adverse effects of this medication are dizziness, dry mouth, insomnia (lack of sleep), nervousness, somnolence (increased sleep), agitation, anxiety, confusion, hypertonia (increased tone), paresthesia (increased numbness), tremor, nausea, sweating, and sexual dysfunction. Anorexia, depersonalization (a state in which one's thoughts and feelings become unreal), agitation,   abnormal dreams, headache, akathisia (it is a movement disorder characterized by a feeling of inner restlessness and inability to stay still), visual disturbances, tinnitus (ringing sound in the ears), tachycardia (increased heart rate), palpitations (increased throbbing of the  heart), hypertension (increased blood pressure), vasodilatation (increased dilatation of blood vessels), dyspnea (shortness of breath), yawning , GI upset, rash, pruritis (intense, severe itching), urinary disorders, menstrual disorders, asthenia (weakness of the muscle), fatigue, chills, raised  cholesterol, weight change. Rarely, neuroleptic malignant syndrome and  GI bleeding may also be seen with the use of this drug.  There are reports of hyponatremia (decreased sodium) and SIADH (a condition in which there is a retention of water in the body).

This medicine is contraindicated in patients with a very high risk of serious cardiac ventricular arrhythmias and uncontrolled hypertension.

  • Do not chew, crush, divide or dissolve extended release capsules in water. Swallow them whole. Capsule contents may be sprinkled onto a spoonful of applesauce and swallowed whole without chewing.
  • Empty bladder(where urine is held) before taking this medication.
  • Change your position slowly from sitting or lying to standing.
  • On the start of therapy, the patient should be watched carefully for suicidal tendency by the caregiver or family of the patient.
Take this medication with meals at the same time daily.
Avoid alcohol and caffeine during therapy
Do not stop taking this medicine abruptly, gradually lower the dose and then stop. Consult your doctor for more advice.
Do not take aspirin or Non-Steroidal Anti Inflammatory Drugs (used for pain and fever) during therapy with this medication.
This medication is not recommended for use in children.
This medication is contraindicated for use in pregnancy. Please consult your doctor for further assistance. 
This drug is not recommended for use during lactation. Please consult your physician for further assistance. 
Use this medication cautiously in patients with moderate to severe kidney or liver impairment, liver cirrhosis, heart disease, history of epilepsy, drug abuse and mania. It should also be carefully used in bleeding tendencies. Monitor Bp and serum cholesterol while using this medication. Re-evaluate patients on long term therapy of this drug. Advise patients to report the development of the rash with the use of this drug. Withdraw gradually over at least 1 week or 2 weeks if high doses for > 6 weeks. Monitor patients with the risks for suicidal behavior. Dose increases may be detrimental in patients who develop akathisia (a movement disorder characterized by a feeling of inner restlessness and inability to stay still) with the use of this medicine. Use this drug cautiously in patients with risk factors for QT prolongation or serious arrhythmia. Hypovolemia, raised IOP, the risk of narrow-angle glaucoma, micturition disorders (problems in passing urine) and in elderly.    

Disclaimer

Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.

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