view bucket

view bucket

Rs.12.75/Pack
Rs 15.00

0 xr tablet(s)/Pack

Pack Size : 5x10's xr tablet

We are sorry, the item you selected is currently out of stock


NOTIFY ME WHEN AVAILABLE
warning icon

Prescription Required

Xormet 1gm xr tablet

Xormet 1gm xr tablet is composed of

Metformin (1gm)

Primarily used for

Type 2 diabetes

Belongs to the category

Diabetes Management

Precaution:

Assess risk factors for lactic acidosis (buildup of lactate causing acidic pH of blood stream). Discontinue immediately if metabolic acidosis (overproduction of acid in the body) is suspected. Monitor renal (kidney) function at least annually. Discontinue the medicine for 48 hours before and after the elective surgery. 

  • hbl-logo
  • 20% OFF
  • alfalah-logo
  • 20% OFF
  • cash-logo
  • 15% OFF
For Medical Professionals
First
Second
Third

Metformin C4H11N5

Molecular Weight: 129g/mol
Dissociation Constant: -0.5
Indication

It is primarily indicated for treating Diabetes Mellitus type 2 and for prevention of diabetes. Orphan: Poly cyctic Ovary Syndrome. The molecule has been known to regulate triglyceride and LDL chloestrol level and has been found to be useful as weight reducing agent.

Mechanism of Action

It is responsible for reducing glucose absorption and enhancing insulin cell sensitivity.

Dosage

Strength: 1gm

Form: xr tablet

Dosing interval: 8-24 Hr

Maximum Dose: 2550 mg/day is well tolerated.

Dialyzable:Yes

Maintainance dose

Type 2 Non Insulin Dependent Diabetes Mellitus: Immediate Release: 500mg twice daily or 850mg per day then, 500mg three times a day. Extended Release: Glucophage XR: 500mg daily; titrate 500mg daily every week. Poly Cystic Ovary syndrome: 1-2g every day orally

Hepatic Adjustment

Risk of Lactic acidosis; Avoid)

Renal Adjustment

In patients with eGFR (glomerular filteration rates less than30ml/min/1.73m2 it is contraindicated. However, in patients eGFR 30-45ml/min/1.73m2 the therapy is not recommended.

  • pregnant

    Pregnancy

    Research on animals showed no effect and no human research was conducted. Or research on animals have shown some degree of effect but human research did not show any effects.

  • mother

    Lactation

    The medicine has shown studies that it enters mothers milk and hence not recommended.

ContraIndication
Cautions

Lactic Acidosis (black Box Warning). May cause ovulation in premenopausal women. May impair B12 and Ca absorption (monitor closely).

Pharmacokinetics

Time of onset: It is known to produce the action within 1-3 hours of administration as per researches conducted.

Tmax: For immediate release tablets the volume of distribution is known to be 650 Liters

Bioavailability: 50-60% (fasting condition)

Protein Binding : It is least bound to protein after administration as per studies.

Elimination Half Life (t1/2): 6 Hr

Metabolism: Not by Liver

Volume of Distribution (Vd): For immediate release tablets the volume of distribution is known to be 650 Liters

Metabolites:

There has not been any metabolites identified as it is reported that metformin is not metabolized.

usesUses of Xormet

This medicine is indicated in maturity onset diabetes either alone or with sulphonylureas. It is also used as adjuvant therapy in insulin dependent diabetes, particularly in obese patients.

side-effectsSide effects of Xormet

GI upset, taste disturbance, abnormal liver function tests, hepatitis (inflammatory condition of liver), skin reactions, reduced B12 absorption are some of its side effects. Rarely it may cause lactic acidosis (buildup of lactate causing acidic pH of blood stream).

pillsWhen not to use Xormet

This medicine is contraindicated in patients with diabetic ketoacidosis (life threatening condition in which liver breaks down fats into ketones for energy) or precoma (a state of near unconsciousness), renal (kidney) or hepatic (liver) impairment, acute conditions predisposing to renal impairment, cardiac or respiratory failure, recent myocardial infarction (heart attack), alcoholism and in patients with administration of iodinated contrast materials.

food-pillsHow to take Xormet

This medicine should be taken with food.

D.N.AHow Xormet works

Metformin works in two ways; It helps to stop the liver producing new glucose. It helps to overcome insulin resistance by making insulin carry glucose into muscle cells more effectively

pills Expert Advice for Xormet

Avoid this medication if:

  • You are allergic to this medicine or its contents 

Consult your doctor if:

  • You are pregnant, planning to have a child, or breastfeeding.
  • If you are avoiding unwanted pregnancy, so that your doctor may suggest a suitable form of birth control. Due to Metformin's effects on ovulation and pregnancy.
  • You have any sort of digestive problems after taking this medicine: Nausea, vomiting, diarrhea, etc.
  • You have a medical history of: Liver diseases, kidney diseases, congestive heart failure, or lung disease.
  • If you are about to undergo any medical or surgical treatment. 
  • If you are about to undergo any CT scan, or X-ray, as it may interact with the dyes used in some pf these procedures.
  • If you have a B12 deficiency, are anemic, or are developing symptoms of anemia, Such as: lethargy, aches and pains,  or a pale appearance to the skin. 

Be careful about:

  • Having your meals on time to maintain blood sugar levels.
  • Taking the medicine timely, in the way that your physician has prescribed (with food), this will help avoid digestive disturbances.
  • Alcohol consumption.
  • Avoiding dehydration in any form.

Q: What family of drugs does this medicine belong to?
Q: Does this medicine contain hormones, or insulin?
Q: Can this drug be used with thyroid medications, and steroids?
Q: What is lactic acidosis and does this medication cause it?
Q: How long should I use this medication for?
Q: Can this medicine cause low blood sugar?
Q: What do I do if I miss a dose?
Q: What will happen if I skip a meal?
Q: Will this medicine make me loose or gain weight?
Q: Can this medication cause any Vitamin deficiency or anemia?
Q: Is it safe to use in patients with liver disease?

Warnings

  • wine-bottle

    Alcohol

    Please avoid consuming alcohol when taking this medicine.

  • pregnant

    Pregnancy

    This medicine is safe to use in pregnant females. No evidence of risk found. 

  • mother

    Breast Feeding

    This medicine is contraindicated in lactating females.

Number of survey's Available: 0

LegitScript has reviewed Dawaai.pk as part of our certification program, and has determined that it meets our standards for legality, safety and transparency