Prescription Required
Trimetazidine is a piperazine derivative indicated for the symptomatic treatment of stable angina pectoris in patients inadequately controlled or intolerant to first line therapies.
Acidic conditions, caused by anaerobic metabolism and fatty acid oxidation, in response to myocardial ischemia, activate sodium-hydrogen and sodium-calcium antiport systems. The increased intracellular calcium decreases contractility.
It is used in Prophylactic treatment of episodes of angina pectoris, adjunct symptomatic treatment of vertigo and tinnitus (dizziness and ringing sensation in ear), adjuct treatment of visual disorders of a circulatory origin.
Nausea, vomiting
Risk cannot be ruled out
Contraindicated or not recommended
No
Kidney failure, severe liver failure, recommended for acute angina attacks, not for initial treatment of unstable angina or MI.
trimetazidine has no contraindications, and can therefore be prescribed even when other anti-anginal agents are contraindicated.
What is trimetazidine and what is its use?
Trimetazidine is an anti anginal drug that is used to treat angina pectoris.
Can I crush trimetazidine before taking it?
No, you are not supposed to crush or chew the tablet before taking it. You should swallow it whole with a glass of water.
Is it necessary to take trimetazidine with meals?
Yes, it is recommended that you take trimetazidine with meals only. However, there has been some drug-food interactions reported which may alter the way the drug works. Please consult your doctor to discuss any food interactions before starting therapy with this drug.
Can trimetazidine be a source of depression and anxiety?
Depression and palpitations (unpleasant awareness of your own heartbeat) and are some of the rare reported side effects of trimetazidine. Please consult your doctor for further assistance if you experience this side effect.
Can I take trimetazidine while on cancer therapy?
Trimetazidine has shown severe interactions with the drug metoclopramide which is used to prevent nausea and vomiting caused by cancer chemo and radiotherapy. Consult your oncologist/doctor regarding this matter.
Is trimetazidine recommended in children?
No, trimetazidine is only recommended in adults.
Should I stop taking trimetazidine if breastfeeding?
Trimetazidine is contraindicated in nursing/breastfeeding women and you may stop its use before starting to nurse. For further assistance, consult your doctor.
Does trimetazidine have an effect on diabetics taking it?
Trimetazidine has been reported to provide some beneficial effects to those suffering from diabetes by improving their HbA1C and blood sugar levels.
Disclaimer
Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.
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