Lipiget is indicated as an adjunct to diet for the reduction of elevated cholesterol, LDL-Cholesterol, apolipoprotein B, and triglycerides and to increase HDL-cholesterol in patients with primary hypercholesterolemia, heterozygous familial and non-familial hypercholesterolemia, and combined (mixed) hyperlipidemia (Fredrickson types 2a and 2b).
Lipiget (Atorvastatin) is a selective, competitive inhibitor of HMG-CoA reductase, the rate limiting enzyme responsible for the conversion of 3-hydroxy-3-methyl-glutaryl-coenzyme A to mevalonate, a precursor of sterols including cholesterol.
Lipiget is contraindicated in patients who are hypersensitive to any component of this medication, who have active liver disease or unexplained persistent elevations of serum transaminases exceeding three times the upper limit of normal, who are pregnant, who are breast feeding, or in women of childbearing potential who are not using adequate contraceptive measures. Lipiget should be administered to women of childbearing only when such patients are highly unlikely to conceive and have been informed of the potential hazards to the fetus.
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