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It is primarily indicated for treating Diabetes Mellitus type 2.
it is known to Increase the B cell insulin secretion of the pancreas. It enhances insulin sensitivity and basal insulin secretions. Its short acting and more potent.
Dosing interval: Studies suggests to maintain an interval of once daily or twice daily in few patients after close observance.
Maximum Dose: 320mg per day is well tolerated.
Dialyzable:Use with caution
Average 160mg-200mg as per studies.
Metabolism has been reported to be effected, administer the doses cautiously as per researches.
No adjustments are documented but recommended to be used with with extreme care. However half life may be enhanced in patients with renal imapirments.
Use with caution. Risk for neonates and infants not found.
Kidney and liver insufficient patients must be closely observed while taking Gliclazide, any condition that causes stress and injury may create worsening conditions and patients have to withdraw or discontinue the therapy as well. Alcohol consumption may exaggerate the condition by causing intolerance reactions so close vigilance is suggested.
Time of onset: 4-5 Hr
Tmax: 18 L (Mean)
Protein Binding : 94%
Elimination Half Life (t1/2): 10 Hr
Metabolism: The molecule has been found to be extensively metabolized by liver
Volume of Distribution (Vd): 18 L (Mean)
Hydroxylates and oxidized derivatives (inactive)
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