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Gliclazide C15H21N3O3S

Molecular Weight: 323g/mol
Dissociation Constant: 4.07
Indication

It is primarily indicated for treating Diabetes Mellitus type 2.

Mechanism of Action

it is known to Increase the B cell insulin secretion of the pancreas. It enhances insulin sensitivity and basal insulin secretions. Its short acting and more potent.

Dosage

Strength: 80mg

Form: tablet

Dosing interval: Studies suggests to maintain an interval of once daily or twice daily in few patients after close observance.

Maximum Dose: 320mg per day is well tolerated.

Dialyzable:Use with caution

Maintainance dose

Average 160mg-200mg as per studies.

Hepatic Adjustment

Metabolism has been reported to be effected, administer the doses cautiously as per researches.

Renal Adjustment

No adjustments are documented but recommended to be used with with extreme care. However half life may be enhanced in patients with renal imapirments.

  • pregnant

    Pregnancy

    Not recommended

  • mother

    Lactation

    Use with caution. Risk for neonates and infants not found.

ContraIndication
Cautions

Kidney and liver insufficient patients must be closely observed while taking Gliclazide, any condition that causes stress and injury may create worsening conditions and patients have to withdraw or discontinue the therapy as well. Alcohol consumption may exaggerate the condition by causing intolerance reactions so close vigilance is suggested.

Pharmacokinetics

Time of onset: 4-5 Hr

Tmax: 18 L (Mean)

Bioavailability: 80%

Protein Binding : 94%

Elimination Half Life (t1/2): 10 Hr

Metabolism: The molecule has been found to be extensively metabolized by liver

Volume of Distribution (Vd): 18 L (Mean)

Metabolites:

Hydroxylates and oxidized derivatives (inactive)

Disclaimer

Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.

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