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This medicine is used as an adjunct to diet in hypercholesterolemia (high cholesterol), heterozygous (genetic disorder characterized with markedly increased LDL and cholesterol )and homozygous familial hypercholesterolemia (a condition in which it is difficult to remove bad cholesterol from body), mixed hyperlipidemia (genetic disorder characterized with high lipids (fats), cholesterol and free fatty acids in blood).

Atorvastatin can cause GI upset, myalgia (muscle pain), arthralgia (pain in joints), headache, asthenia (abnormal weakness), insomnia (difficulty in sleeping), dizziness, paraesthesia (abnormal sensation of skin such as tingling, burning, chilling and numbness), hypoaesthesia (reduces sensation in one or more body parts), chest and back pain, pain extremities, epistaxis (bleeding from nose), muscle spasms, joint swelling, abnormal LFTs, raised creatinine kinase, ALT and CPK levels, hyperglycemia (high blood glucose), nasopharyngitis (swelling of nasal passages and back of throat, commonly known as cold) etc. Immune mediated necrotising myopathy (autoimmune muscle disease relatively severe proximal weakness) is also reported.

This medicine is contraindicated in active liver disease, persistent raised liver enzymes. Adequate contraception should be ensured.

  1. Should this medication be taken with meals?

It is advisable to take this medication in the evening as our body produces most cholesterol at night.

 

  1. What are the most common side effects of this medication?

Some common side effects of this medication are insomnia (inability to sleep), UTI (urinary tract infection), loss of appetite and arthralgia (joint pain).

 

  1. What foods must be avoided while taking this medication?

Consult your doctor before consuming grapefruit juice or grapefruit.

 

  1. Does this medication damage your kidneys?

No, this medication may improve kidney function in patients with cardiovascular disease. Consult your doctor with further risks and benefits.

 

  1. Can this medication cause hair loss?

Yes, in some patients it can. Consult your doctor for the risks and benefits associated with this medicine before use.

  • Take with or without meals.
  • Take medicine at the same time each day.
  • Contact prescriber if unrelieved diarrhea (watery stools), fever, unusual muscle cramps, weakness, mood changes, memory changes, yellowing of skin or eyes, easy bruising or bleeding or unusual fatigue (weakness).
  • Take a missed dose as soon as you remember, unless it is likely the time of next dose. Do not double the dose.
  • Avoid high intake of grapefruit juice (>1 litre per day).
  • Take sufficient amounts of fluids (2-3 litres per day), unless restricted by the prescriber.
  • Laboratory tests are important during therapy.
Hyperlipidemia

This medicine is used in combination with diet for treating primary hypercholesterolemia (high cholesterol levels) with or without statin medication, homozygous familial hypercholesterolemia in combination with statin or, if necessary, other medicines, and in combination with diet for treating homozygous familial sitosterolemia (inherited disorder of sterol metabolism).

The patients administered with this medicine may experience headache, abdominal pain, diarrhea, gastrointestinal disturbances, and abnormal liver function tests.

The patients with moderate to severe hepatic (liver) impairment and concomitant use of statin in liver disease should avoid the use of this medicine.

  1. How long does Ezetimibe take to work?

This medicine mostly takes about 2 weeks to show its full effect.

 

  1. Can Ezetimibe be taken at night?

There is no ideal time to take this medicine. It can be taken at any time of the day. However, please ensure that you take it at the same time every day.

 

  1. What food interacts with Ezetimibe?

This medicine may interact with grapefruit and its juice. Please avoid consuming grapefruit during use of this medicine.

 

  1. Is Ezetimibe a statin?

This medicine is a non-statin cholesterol lowering medicine. It reduces the absorption of cholesterol from the intestinal tract.

 

  1. Does Ezetimibe affect liver function?

This medicine does not induce or inhibit the liver enzymes. However, it may affect its function indirectly.

  • Please take this medicine at the same time every day.
  • Please take 2 hours before or 4 hours after bile-acid binding agents.
  • Please take a low-cholesterol diet.
  • Exercise regularly for this medicine to work effectively.
  • Take this medicine with or without meals.
  • Take a low cholesterol diet.
Serum triglycerides, cholesterol and LFTs should be evaluated before the start of therapy, and periodically thereafter.
Please store the tablet form of this medicine at room temperature (18-25 Celsius). Keep medicine away from excessive light and moisture. Please keep it away from children.
Avoid high cholesterol and high fat foods, excessive grapefruit or grapefruit juice and excess alcohol use.
It contains a chemical that interferes with body ability to breakdown statin medications.
Take the missed dose as soon as you remember. But do not take if it has been more than 12 hours since the last dose.
It treats high cholesterol by lowering bad cholesterol (LDL) and raising good cholesterol (HDL).
It can be used in the prevention of heart attack and stroke.
Yes, you are advised to add exercise to your daily activities along with a low-fat diet.
If it is taken as prescribed by your doctor, the cholesterol levels drop within 2 weeks.
Avoid foods that are high in calories like chips, burgers, fried food, etc. and eat a low-fat, low-cholesterol diet only.
You can take it with or without food.
You can take this medication at any time of the day.
This medicine is contraindicated in pregnant females. Consult your doctor before using this medication.
This medicine is contraindicated in nursing females.
Please avoid consuming alcohol when taking this medicine.
Elderly patients and patients with a history of alcohol abuse or liver disease, renal (kidney) impairment, hypothyroidism (low thyroid levels in blood), history of muscle toxicity or muscle disorders are sensitive to the drug. Liver function tests should be performed before and during the therapy. Advice patients to report unusual muscle weakness or pain, maintain creatinine kinase levels, withdraw if liver > 5 x ULN. There may be a risk of Interstitial lung disease (inflammation and scarring of tissue that surrounds lung’s air sacs, blood vessels and airways); advice  patients to report symptoms including dyspnea (difficulty in breathing), non-productive cough, fatigue (weakness), weight loss, fever. Risk of new onset of diabetes; risk factors include hypertension (high blood pressure), raised triglycerides, BMI and fasting glucose at baseline. There is risk of stroke and transient ischemic attack (a stroke that lasts for a few minutes in which blood supply to the part of brain is briefly stopped).
The effects of this medicine in pregnant females are unknown. Therefore, please consult your doctor before use.  
This medicine is contraindicated or not recommended to be used in lactating women. 
The patients with unexplained muscle weakness or pain should use this medicine cautiously. Please monitor liver function and creatine kinases levels during use.

Disclaimer

Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.

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