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Simbex 20mg/10mg tablet

Brand: Searle

Prescription Prescription Required

Simbex 20mg/10mg tablet is composed of Ezetimibe (20mg)Simvastatin (10mg)

Ezetimibe is a medicine that is used to lower the level of cholesterol as well as fatty compounds in the blood. It can be taken alone or in conjunction with other medicines that lower the cholesterol level. Patients are instructed to combine this medicine with a strict diet and exercise routine to achieve the best results. Ezetimibe helps by lowering cholesterol absorbed by your body from your food. Lowering cholesterol may aid in the prevention of heart attacks and strokes.


How To Use

  • Take Ezetimibe by mouth, generally once every day either with or without meal, as advised by your doctor.
  • The dosage is determined by your health condition as well as your reaction to treatment.
  • Swallow Ezetimibe tablet with water.
  • Do not crush, break or chew the tablet.
  • Do not stop taking Ezetimibe without first consulting your doctor.

Expert Advice

  • Please take this medicine at the same time every day.
  • Please take 2 hours before or 4 hours after bile-acid binding agents.
  • Please take a low-cholesterol diet.
  • Exercise regularly for this medicine to work effectively.
  • Take this medicine with or without meals.
  • Take a low cholesterol diet.

Primary Uses


  • Ezetimibe is used to lower unusually high lipid levels in the blood.
  • Ezetimibe is used to treat homozygous hereditary hypercholesterolemia, an inherited disorder characterized by high levels of cholesterol as well as lipids in the blood.
  • Ezetimibe is used to treat sitosterolemia, a genetic disorder marked by a plant sterols buildup in the tissues and blood.

Side Effects

The patients administered with this medicine may experience headache, abdominal pain, diarrhea, gastrointestinal disturbances, and abnormal liver function tests.



Ezetimibe should only be used during pregnancy if absolutely necessary. Pregnant females should consult their doctors before using Ezetimibe.


It is not known whether Ezetimibe secretes into breastmilk or not. Lactating females should consult their doctors before using Ezetimibe.


Drowsiness and weariness are possible adverse effects of Ezetimibe. Do not drive until you have determined how Ezetimibe affects you.


Ezetimibe is not recommended for use in patients with liver diseases.


People with kidney diseases should consult their doctors before using Ezetimibe.


Interaction of Ezetimibe with alcohol is not known. It is advised to consult your doctors before alcohol consumption.


Inform your doctor if you have Ezetimibe hypersensitivity or allergy to other components present in Ezetimibe. Because of the increased danger of bleeding, Ezetimibe should be taken cautiously in patients on anticoagulants like warfarin. Such patients should have their International Normalized Ratio (INR) closely monitored. Depending on the clinical state, appropriate dose changes may be required. Ezetimibe's safety and efficacy in children under the age of ten have not been verified clinically. Ezetimibe may result in rhabdomyolysis, a severe disorder marked by muscle weakness and discomfort. Muscle weakness, tenderness or soreness should be reported to a doctor as soon as possible. Depending on the clinical state, appropriate dose modifications or substitution with a reasonable replacement may be needed.


  • Ezetimibe should not be used in individuals who have a known hypersensitivity to ezetimibe or other components that may be present in this medicine.
  • Ezetimibe is not recommended for people who have moderate to severe liver diseases.


What does this medication treat?

It treats high cholesterol by lowering bad cholesterol (LDL) and raising good cholesterol (HDL).

Against what medical conditions can it be used prophylactically?

It can be used in the prevention of heart attack and stroke.

Are there any specific considerations while taking this medicine?

Yes, you are advised to add exercise to your daily activities along with a low-fat diet.

How long does it take for ezetimibe to work?

If it is taken as prescribed by your doctor, the cholesterol levels drop within 2 weeks.

What foods should be avoided while taking while taking this medication?

Avoid foods that are high in calories like chips, burgers, fried food, etc. and eat a low-fat, low-cholesterol diet only.

Can I take it with food?

You can take it with or without food.

At what time of the day is it to be taken?

You can take this medication at any time of the day.

I am pregnant, can I use this medication?

No, this medication is contraindicated in pregnant females.

Is it safe to drive while using this medication?

As a side effect, patient might experience dizziness which makes it unsafe to drive.

Can I stop this medicine when I feel better?

Consult your prescriber before stopping this medication despite the fact

For how long does it take simvastatin to show its effect?

It starts to show its effect within a few minutes of administration.

How effective is simvastatin?

Simvastatin is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. It belongs to a group of medicines known as "statins." It works by reducing the amount of cholesterol made by the liver. Lowering "bad" cholesterol and triglycerides and raising "good" cholesterol decreases the risk of heart disease and helps prevent strokes and heart attacks.


Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.


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