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It is an angiotensin II antagonist (acts against angiotensin 2 hormone) and is indicated in the treatment of essential hypertension (primary hypertension i.e rise in blood pressure).

Patients using this medication may at times experience dizziness, headache, edema (collection of body fluid in tissues and body cavities), and fatigue. If you experience any of these symptoms for a prolonged period of time, please consult your doctor.

This medicine is contraindicated in cases of biliary obstruction (blockage of bile carrying duct), primary aldosteronism (hormonal disorder leading to high blood pressure), severe liver & in severe kidney impairment.

  • This medicine can be taken with or without meals
  • If there is prolonged diarrhea, nausea/vomiting, joint pain, back pain, chest pain, palpitations, unrelieved headache or flu-like symptoms, then immediately call your doctor.
  • Exercising in hot weather & excessive intake of alcohol should be avoided.
  • Keep a check on blood glucose levels and inform prescriber of the changes.
Hypertension

This medicine is used to treat hypertension (high Blood pressure), myocardial ischemia (decreased blood supply to heart muscle) associated with stable (chest pain triggered by activity), or vasospastic angina (chest pain triggered with vasospasm of coronary artery).

 

 

Patients using this medicine may commonly experience headache, edema, fatigue, nausea, dizziness (lightheadedness), flushing (reddening of the skin), rashes, and gingival hyperplasia (overgrowth of gum). Patients may rarely experience alopecia (spot baldness), pruritus (itching), abdominal and back pain, hyperglycemia, increased urination, palpitations, and GI (stomach) upset. 

This medicine is contraindicated in patients having history of cardiogenic shock (inability of heart to pump enough blood), aortic stenosis (narrowing of aortic valve opening), unstable angina (chest pain triggered by minimum or no activity), severe hypotension, unstable heart failure following MI, and hypersensitivity to dihydropyridines.

 

  1. What is the best time to take this medicine?

It does not matter what time of day you take this medicine (morning or evening) but it is best to take it at the same time every day when you are most likely to remember, for more even blood levels and therefore effectiveness.

 

  1. What to avoid while taking this medicine?

Do not eat or drink lots of grapefruit or grapefruit juice. This is because grapefruit can increase the concentration of drug in your body and worsen side effects.

 

  1. Is this medicine harmful to kidneys?

This medicine should not cause kidney damage and is used to treat high blood pressure and slow the progression of chronic kidney disease.

 

  1. Is this medicine safe to use?

It is generally a safe and effective drug, but it may cause side effects in some people.

 

 

  1. How to take this medicine?

Swallow the tablet with a drink of water. You can take this medicine before or after meals.

  • Take with or without meals.
  • To avoid stomachache, take with meals.
  • Take missed dose as soon as you remember and next dose in 24 hours.
  • Contact prescriber if there is unrelieved headache, vomiting, weight gain, palpitations, or difficulty in breathing.
  • Check blood pressure regularly.

 

Angina and Hypertension
This medication is used for treating high blood pressure (hypertension). A normal blood pressure is necessary for prevention of strokes, heart attack, and kidney disease.
Please store this medicine at room temperature (18-25 Celsius). Keep medicine away from excessive light, moisture, and children. Please do not flush medicines down the toilet. Please read the leaflet provided with the medicine for further storage guidance.
According to a study nausea and vomiting is experienced in 68% of the patients, abdominal pain in 50%, bloating in 41% & fatigue in 68%. But all these symptoms disappear when Olmesartan is stopped.
It produces its effect by first blocking angiotensin II receptor (ARB). Hence by blocking this substance, the tightening of the blood vessels is reduced and Olmesartan finally relaxes & lowers the pressure on blood vessels.
Natural drinks reducing BP include tomato juice, beet juice, prune juice, pomegranate juice, skim milk & tea.
Drugs like aliskiren, lithium, drugs increasing potassium level in blood (like ACE inhibitors benazepril/lisinopril, birth control pills having drospirenone).
As per FDA recommendation, simvastatin dosage should be limited to 20 mg daily while taking amlodipine. Also, all the CYP3A4 enzyme inhibitors like diltiazem, ketoconazole, itraconazole & ritonavir should be avoided while taking amlodipine.
You don’t need to worry about the swelling, as it is one of the very common adverse effects of the drug. This will go off once you withdraw its use. But you still need to consult your physician if the condition is getting worse.
You are not advised to do so abruptly nor are you supposed to make this decision by yourself. Consult with your physician, who will most probably advise for a gradual withdrawal. This is done to avoid the chest pain and relapse of high blood pressure, which is usually observed in such scenarios.
It is available in tablet, drops and I/V (intravenous) forms.
No, the drug is not safe for any kind of kidney or liver disease. Consult your physician for an alternative.
It doesn’t really matter at what time of the day you take amlodipine, but it is best to take it at the exact time every day, for more even blood levels & more effectiveness of the medicine.
New research shows that administering blood pressure medicines at bedtime effectively helps to reduce your risk of illness or death due to blood vessel & heart disease. Timings are important as BP follows a daily rhythm. It is high during the day & falls at nighttime.
It is seen that titration of amlodipine from 5-10 mg every day in patients not responding to the treatment with 5 mg dose showed significant decrease in BP.
This medicine is contraindicated in pregnant females.
This medicine is contraindicated in lactating mothers. Consult your doctor if there's no other alternative medicine.
Please avoid consuming alcohol when taking this medicine.
This medicine should be used with caution on individuals suffering from intravascular volume depletion, aortic or mitral valve stenosis (narrowing of heart’s mitral and aortic valve), obstructive hypertrophic cardiomyopathy, primary aldosteronism, liver impairment. Also, in individuals having excessively low BP with ischemic heart disease or ischemic cerebrovascular disease which may result in myocardial infarction (MI) or stroke.
This medicine is not safe to be administered in pregnant females. Consult your doctor for more information.
This medicine is not recommended for lactating females.
Please avoid driving when taking this medicine as it may affect your ability to drive.
This medication should be used with caution in patients who recently had MI (heart attack), or have history of impaired hepatic (liver) function, hypertensive crisis, and heart failure.

Disclaimer

Dawaai's intention is to make sure that it's consumers get information that is accurate, reviewed by an expert and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, which may not cover all possible precautions, side effects, contraindications or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.

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