Precaution: Use this drug with caution in hematological depression, chronic liver disease, psychiatric disorder, ascities (accumulation of fluid leading to abdominal swelling), pleural effusion, diabetes, and in elderly. Perform blood, urine, kidney, and liver test. Monitor oral changes, and perform chest X ray. Advise patient to report difficulty in breathing, cough, or fever. There is also a risk of diarrhea, vomiting, and ulcerative mucosal inflammation of mouth. Male patients should consider sperm preservation before treatment.